Testosterone
Intervention2 papers4 findingsPubChem 6013ChEBI 17347
Outcomes
4Cognitive function
no changein humans1Low certainty
1 study
Cognitive function
no changein humans1Low certainty
Testosterone has no effect on cognitive function in humans.
Reviewmenopause
Testosterone Therapy for Cognition in Menopause: Systematic review and meta-analysis · Reproduction & fertility · 29 Sep 2026
Major adverse cardiovascular events
no changein humans1
1 study
Major adverse cardiovascular events
no changein humans1
Testosterone has no effect on major adverse cardiovascular events in humans.
Reviewhigh cardiovascular riskmales
Key Findings on the Efficacy and Safety of Testosterone Therapy from Two Large Randomized Trials · The Journal of clinical endocrinology and metabolism · 26 Sep 2026
Mood
upin humans1
1 study
Mood
upin humans1
Testosterone improves mood in humans.
Reviewage-related syndromic androgen deficiencymales
Key Findings on the Efficacy and Safety of Testosterone Therapy from Two Large Randomized Trials · The Journal of clinical endocrinology and metabolism · 26 Sep 2026
Sexual function
upin humans1
1 study
Sexual function
upin humans1
Testosterone improves sexual function in humans.
Reviewage-related syndromic androgen deficiencymales
Key Findings on the Efficacy and Safety of Testosterone Therapy from Two Large Randomized Trials · The Journal of clinical endocrinology and metabolism · 26 Sep 2026
Latest
85-ARI use is tied to lower laryngeal cancer risk in men
In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio…In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio, 0.83).
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle…Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
Childhood ADHD brain patterns link to markers of late-life aging
In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging…In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging markers and poorer late-life cognition.