SENP7
- 2 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 1 more
- Humans1
- Animals1
- In silico1
Effects
4Antitumour efficacy
downin mice1
1 study
Antitumour efficacy
downin mice1
SENP7 decreases antitumour efficacy in mice.
“targeting SENP7 in B cells improved the antitumour efficacy of anti-PD-1 therapy”
Animalsanti-PD-1 therapyB cells
International journal of biological sciencesDec 9, 2025
SIRT1
upin mice1
1 study
SIRT1
upin mice1
SENP7 increases SIRT1 in mice.
“sentrin-specific protease 7 (SENP7) promotes regulatory B-cell (Breg) differentiation and inhibits senescence by activating the expression of the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) via deSUMOylation”
AnimalsB cells
International journal of biological sciencesDec 9, 2025
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
SENP7 inhibits cellular senescence in mice.
“sentrin-specific protease 7 (SENP7) promotes regulatory B-cell (Breg) differentiation and inhibits senescence”
Animalsregulatory B cells
International journal of biological sciencesDec 9, 2025
Regulatory B-cell differentiation
upin mice1
1 study
Regulatory B-cell differentiation
upin mice1
SENP7 increases regulatory B-cell differentiation in mice.
“sentrin-specific protease 7 (SENP7) promotes regulatory B-cell (Breg) differentiation and inhibits senescence”
Animalsregulatory B cells
International journal of biological sciencesDec 9, 2025
Associations
1Benign prostatic hyperplasia
upin humans1
1 study
Benign prostatic hyperplasia
upin humans1
SENP7 raises the risk of benign prostatic hyperplasia in humans.
“ITPR1 and SENP7 were associated with increased risk”
Humans
The journals of gerontology. Series A, Biological sciences and medical sciencesApr 24, 2025