Naringenin

Intervention1 paper3 findingsPubChem 439246ChEBI 17846

  • Animals1

Outcomes

3

Serotonin

upin rats1Very low certainty

1 study

  1. Naringenin increases serotonin in rats.

    Animalsin ovariectomized ratsprefrontal cortex

    TRPM3 inhibition reverses depressive behaviors in rats · The Journal of pharmacology and experimental therapeutics · 22 Jul 2026

Serotonin →

Inflammation

downin rats1Very low certainty

1 study

  1. Naringenin decreases inflammation in rats.

    Animalsin ovariectomized ratshypothalamus

    TRPM3 inhibition reverses depressive behaviors in rats · The Journal of pharmacology and experimental therapeutics · 22 Jul 2026

Inflammation →

Depressive-like behavior

downin rats1Very low certainty

1 study

  1. Naringenin decreases depressive-like behavior in rats.

    Animalsin ovariectomized ratsbrain

    TRPM3 inhibition reverses depressive behaviors in rats · The Journal of pharmacology and experimental therapeutics · 22 Jul 2026

Latest

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The Journal of Pharmacology and Experimental TherapeuticsAnimals

TRPM3 inhibition reverses depressive behaviors in rats

In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.

Synaptic transmission

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