TFAM
Gene1 paper4 findingsHGNC 11741MGI 107810NCBI Gene 7019Taxon 9606
- Animals1
Effects
3Immune response
upin mice1
1 study
Immune response
upin mice1
TFAM improves immune response in mice.
Animalsduring influenza infectionCD8+ T cells
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Inflammation
downin mice1
1 study
Inflammation
downin mice1
TFAM decreases inflammation in mice.
Animalsduring influenza infectionCD8+ T cells
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Oxidative phosphorylation
upin mice1
1 study
Oxidative phosphorylation
upin mice1
TFAM improves oxidative phosphorylation in mice.
Animalsin CD8+ T cells
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Upstream
1Human aging
downin human cells1
1 study
Human aging
downin human cells1
Human aging decreases TFAM in human cells.
Cellsage-associatedCD8+ T cells
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Latest
1TFAM deficiency in T cells worsens viral lung pathology and weakens immunity
Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.