Gladstone Institutes

• Michael Ryan Corces

  Assistant investigator

• Veronika Dubinkina

  Bioinformatic fellow

• Catherine Tcheandjieu

  Assistant investigator

• Isha Himani Jain

  Assistant investigator and professor

• Andrew Chris Yang

  Assistant investigator

• Yadong Huang

  Senior investigator

• Christina Theodoris

  Lead investigator

• Seth Shipman

  Assistant investigator

• Jorge J Palop

  Assistant investigator

• Misha Yuri Zilberter

  Principal staff research scientist

• Dennis R Tabuena

  Postdoctoral scholar

• Ken Nakamura

  Associate investigator

• Bruce R Conklin

  Senior investigator

• Lennart Mucke

  Director/senior investigator

• Todd C McDevitt

  Senior investigator

• Melanie Maria Ott

• Vaishaali Natarajan

  Lead investigator

• Steven M Finkbeiner

  Director/senior investigator

• Deepak Srivastava

  Senior investigator

• Mara Kauss

  Lead investigator

Sources: reporter.nih.gov, openalex.org

• NCT00071240

  Collaborator, Phase 2, Completed, 22 people, Oct 17, 2003

• National Institute on Aging

  R01, Functionalization of rare noncoding variants as drivers of Alzheimer's disease risk, R01AG093119, $846K, 2026–2031, Sep 9, 2026

• National Heart, Lung, and Blood Institute

  K99, Linking microbes to cardiovascular-associated metabolites using knowledge-based machine learning, K99HL188571, $134K, 2026–2031, Sep 4, 2026

• National Heart, Lung, and Blood Institute

  K01, Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations, K01HL173644, $179K, 2024–2029, Aug 26, 2026

• National Center for Complementary and Alternative Medicine

  R01, A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies, R01AT013724, $1.3M, 2025–2030, Aug 6, 2026

• National Institute of Neurological Disorders and Stroke

  R01, Elucidating Microvascular Contributions to Cognitive Impairment at Single-Cell Resolution, R01NS128909, $1.2M, 2024–2028, Jul 14, 2026

• National Institute on Aging

  R01, Study Susceptibility and Resistance to ApoE4 in Alzheimer's Disease, R01AG076647, $879K, 2022–2027, Jul 7, 2026

• BrightFocus Foundation

  Alzheimer's Disease Research: Standard, Mapping cell state transitions in brain aging to predict rejuvenating therapeutic targets, A2026030S, $300K, 2026–2029, Jul 1, 2026

• National Institute on Aging

  R01, Mitochondrial DNA Compaction and the Accumulation of Mutations with Age and Stress, R01AG092732, $794K, 2025–2030, Apr 9, 2026

• National Institute on Aging

  R01, Harnessing novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease, R01AG092683, $817K, 2025–2030, Apr 6, 2026

• National Institute on Aging

  R01, Targeting Nell2 and GABAergic Dysfunction to Mitigate APOE4-Driven Pathogenesis in Alzheimer's Disease, R01AG092390, $779K, 2025–2030, Mar 25, 2026

• National Institute on Aging

  R61, Enhancer-AAVs to monitor and restore cell-type selective inhibitory deficits and circuit dysfunction in humanized Alzheimer's disease models, R61AG094667, $1.5M, 2025–2027, Jul 29, 2025

• National Institute on Aging

  R01, Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease, R01AG071697, $801K, 2021–2026, May 12, 2025

• National Institute on Aging

  F32, Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model, F32AG085961, $76.8K, 2023–2025, Nov 19, 2024

• National Institute of Neurological Disorders and Stroke

  RF1, Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology, RF1NS139975, $5.4M, 2024–2027, Sep 19, 2024

• National Institute on Aging

  R01, Defining Strategies to Target Energy Failure in Metabolically Vulnerable Human Cells, R01AG065428, $621K, 2020–2026, Apr 22, 2024

• National Institute on Aging

  R01, Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic Cells, R01AG065540, $724K, 2020–2025, Apr 18, 2024

• American Heart Association

  Second Century Early Faculty Independence Award, Addressing disparities in cardiovascular risk burden and health outcomes across populations, 23SCEFIA1156913, $300K, 2023–2026, Jul 1, 2023

• National Institute on Aging

  R01, Apolipoprotein E4-related Electrophysiological and Metabolic Impairments in Aging and Alzheimer's Disease, R01AG061150, $656K, 2019–2024, Jan 4, 2023

• National Eye Institute

  R01, Therapeutic genome editing to treat Best disease, R01EY028249, $412K, 2017–2022, Jun 30, 2021

• National Institute on Aging

  RF1, Optogenetic dissection of cellular and circuit mechanisms of network dysfunction and amyloid deposition in mouse models of Alzheimer's disease in vivo, RF1AG062234, $213K, 2018–2023, Jun 29, 2021

Sources: reporter.nih.gov, openalex.org

• Hypoxia rescues complex 1-associated disease caused by proteostatic defects

  Jul 8, 2026

• Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer's disease pathogenesis

  R01AG061150, Apr 3, 2026

• Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease

  Feb 25, 2026

• Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis

  Jan 30, 2026

• Targeted delivery of genome editors in vivo

  Jan 12, 2026

• Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

  Oct 19, 2024

• Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection

  May 7, 2024

• Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

  Sep 8, 2022

• Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models

  Oct 7, 2021

• Caloric restriction disrupts the microbiota and colonization resistance

  Jun 23, 2021

• Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

  Sep 19, 2018

• Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice

  Aug 24, 2018

• Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content

  Apr 16, 2018

• MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

  Apr 10, 2018

• Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1

  Nov 30, 2017

• Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

  Sep 5, 2017

• Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice

  Aug 8, 2017

• Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease

  Nov 11, 2016

• Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

  Sep 20, 2016

• Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells

  Jul 28, 2016

Sources: openalex.org, api.crossref.org

• Development of a humanized anti-fibrin monoclonal antibody for the treatment of neuroinflammatory and retinal diseases

  Grants or research support, Dec 17, 2025

• A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain

  Consulting or advice, Shares or equity, Founder, Oct 29, 2025

• Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

  Consulting or advice, Fees or honoraria, Patents or royalties, Grants or research support, Board or leadership role, Nov 4, 2024

• Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

  Consulting or advice, Shares or equity, Founder, Oct 19, 2024

• Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models

  Patents or royalties, Oct 7, 2021

Sources: pubmed.ncbi.nlm.nih.gov

• Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging

  The Journal of clinical investigation, Oct 15, 2026

• Engineered cardiac transcription factor restores vision and reduces frailty in aging mice

  bioRxiv, Oct 2, 2026

• SIRT1 in Senescence: Mitochondria and Immune Crosstalk

  Biology, Sep 26, 2026

• Human brain region shows three phases of gene activity

  Nature, Sep 24, 2026

• Generation of Transgene-Free Naive Human Induced Pluripotent Stem Cells from Somatic Cells Using a Modified Temperature-Sensitive Sendai Virus System

  Methods in molecular biology (Clifton, N.J.), Sep 14, 2026

• Mitochondria-Targeted Natural-Derived Compounds in Cellular Senescence: Mechanisms, Therapeutic Potential, and Future Directions

  Biology, Aug 13, 2026

• CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

  Alzheimer's & dementia : the journal of the Alzheimer's Association, Aug 12, 2026

• Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction

  Neuron, Aug 11, 2026

• Trained immunity links hematopoietic stem cell aging to aging-associated inflammation

  Nature aging, Jul 17, 2026

• Low oxygen extends life in mice with mitochondrial disease

  Nature metabolism, Jul 9, 2026

• Domain-specific proteome remodeling defines mouse myelin aging

  bioRxiv (Cold Spring Harbor Laboratory), Jul 9, 2026

• Diminished transcriptional activity and splicing changes drive gene length-biased rewiring in the aging transcriptome

  Proceedings of the National Academy of Sciences of the United States of America, Jun 16, 2026

• Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s Disease

  eLife, Jun 16, 2026

• Temporal AI model predicts drivers of cell state trajectories across human aging

  bioRxiv : the preprint server for biology, Apr 10, 2026

• Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer's disease pathogenesis

  Nature aging, Apr 4, 2026

• Requirement for oxidation of neuronal ketone bodies in aging and neurodegeneration

  bioRxiv : the preprint server for biology, Apr 3, 2026

• Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles

  medRxiv, Mar 27, 2026

• Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains

  bioRxiv : the preprint server for biology, Mar 27, 2026

• Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound

  Immunity, Mar 22, 2026

• Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning

  Nature biotechnology, Mar 12, 2026