All-cause dementia
Disease2 papers2 findings
- Humans2
Associations
2Smoking
upin humans1Low certainty
1 study
Smoking
upin humans1Low certainty
Smoking raises the risk of all-cause dementia in humans (p < .001).
Humansmultiplicative interaction with APOE ε4
Smoking links to dementia risk mainly in APOE ε4 noncarriers · Biological psychiatry global open science · 30 Jul 2026
DunedinPACE
upin humans1HR 1.3
1 study
DunedinPACE
upin humans1HR 1.3
DunedinPACE raises the risk of all-cause dementia in humans (HR = 1.30, 95% CI [1.10-1.54]).
HumansExam 8, 2005-2008n = 2,606
Epigenetic age links to higher dementia risk in older adults · Neurology open access · 8 Jun 2026
Latest
7GLP-1 agonists linked to lower dementia risk after COVID-19
GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19…GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors.
Epigenetic age links to higher dementia risk in older adults
In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia…In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).
Smoking links to dementia risk mainly in APOE ε4 noncarriers
Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.
Probable REM sleep disorder links to Lewy body dementia
In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.
Early statin use links to lower dementia risk in diabetes
Early statin initiation was associated with a 15% lower 10-year relative risk of dementia compared to no statin treatment in people with type 2…Early statin initiation was associated with a 15% lower 10-year relative risk of dementia compared to no statin treatment in people with type 2 diabetes.
RAS inhibitors linked to lower dementia risk than CCBs
Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).