Total brain volume

Biomarker2 papers2 findings

Humans2

Effects

1

Global cognition

mediatesin humans1

1 study

Total brain volume mediates global cognition in humans (9%; β = 0.005, SE = 0.011).
Humansmediating the MIND diet associationbrainn = 713
MIND diet, cerebrovascular health, and cognition among community-dwelling older adults · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Aug 2026

Global cognition →

Associations

1

Mind diet

upin humans1Low certainty

1 study

Mind diet is associated with total brain volume in humans (β = 0.153, SE = 0.07).
Humansbrainn = 713
MIND diet, cerebrovascular health, and cognition among community-dwelling older adults · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Aug 2026

Latest

20

Neurobiology of AgingHumans21 Sep

Bilingualism modulates baseline brain-cognition relationships in aging: Evidence from the HABS-HD cohort

RadiologyHumans15 Sep

Evaluating the Effect of Neighborhood-level Disadvantage on Brain Health: An Imaging Epidemiology Study

Brain Structure & FunctionHumans8 Sep

Associations between cerebral cortex volume and verbal fluency in community-dwelling adults using magnetic resonance imaging: a cross-sectional observational study

Cerebral Circulation - Cognition and BehaviorHumans6 Sep

Relationship between cardiac index and brain volume in the UK Biobank

Journal of Alzheimer's DiseaseHumans3 Sep

Comparison of baseline characteristics between cognitively normal and mild cognitive impairment and association of white matter hyperintensity trajectories with diagnostic outcomes, cognition, and amyloid-β protein: A longitudinal study

Mild cognitive impairment

medRxivHumansPreprint2 Sep

Left ventricular hypertrophy, brain atrophy and cognitive decline in type 2 diabetes mellitus: Diabetes & Dementia (D2) cohort study

Left ventricular hypertrophy

JAMA Network OpenHumans25 Aug

Age at Menopause and Brain Atrophy Among Older Women

Alzheimer's & DementiaHumans21 Aug

MIND diet, cerebrovascular health, and cognition among community-dwelling older adults

AAIC 2025 AbstractHumans7 Jan

White Matter Hyperintensities on Brain MRI are Related to Brain Atrophy and Accelerated Brain Age

GSA 2025 AbstractHumans3 Jan

Predictors of Cognitive Resilience in the Multi-Ethnic Study of Atherosclerosis