Predictive Value of the Proteomic Aging Clock and APOE Genotype for Incident Alzheimer’s Disease Risk
GSA 2025 Abstract
Abstract
Aims: This study aimed to develop a novel proteomic aging clock (PAC) and evaluate its predictive value, along with APOE-ε4, for Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) risk in a cohort of adults ages 45–64 at baseline (1987–1989) with a median follow-up of 30 years.
