MechanismsHumans
Genome‐Wide Pleiotropy Analysis of Longitudinal Blood Pressure and Harmonized Cognitive Performance Measures
AAIC 2025 Abstract
Abstract
Background: Genome‐wide association studies (GWAS) have identified over 1,000 blood pressure (BP) loci and over 80 Alzheimer's disease (AD) loci. Considering BP is an AD risk factor, identifying pleiotropy in BP and cognitive performance may indicate mechanistic links between BP and AD.
The paper
Moonil Kang, Ting Fang Alvin Ang, Sherral Devine, Lindsay A. Farrer
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Richard Sherva, Shubhabrata Mukherjee, Emily H. Trittschuh, Laura E. Gibbons, Phoebe Scollard, Michael L. Lee, Seo‐Eun Choi, Brandon Skylar Klinedinst, Connie Y. Nakano, Logan C. Dumitrescu, Timothy J. Hohman, Michael L. Cuccaro, Andrew J. Saykin, Walter W. Kukull, David Alan Bennett, Li-San Wang, Richard P Mayeux, Jonathan L Haines, Margaret Pericak‐Vance, Gerald D. Schellenberg, Paul K. Crane, Rhoda Au, Kathryn L. Lunetta, Jesse Mez,Boston University
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
