Research Square
Triglyceride-Glucose Indices, Genetic Susceptibility, and Incident Dementia Risk Across Early CKM Syndrome Stages: A UK Biobank Prospective Cohort Study
Preprint: cohort study of 260,480 peopleBiomarkers
13.64 years, dose-response
Abstract
Background Insulin resistance, indicated by the triglyceride-glucose (TyG) index, is an emerging risk factor for cognitive decline. However, its interplay with genetic susceptibility in determining dementia risk remains unexplored, particularly during the early stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome.
- Dementia
- Cardiovascular-kidney-metabolic syndrome
- Dementia PRS
- Insulin resistance
- Triglyceride-glucose index
- Humans
The paper
Hangzhou Normal University
Research Square, 12 Aug 2026, CC BY, Preprint, not peer-reviewed
