Recombinant human APOE2

Intervention1 paper5 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab

Animals1

Outcomes

Glycolysis

upin mice1

1 study

Recombinant human APOE2 increases glycolysis in mice.
Animalsco-administered with ADTC5synaptosomes4-8 weeks
Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 mice · bioRxiv : the preprint server for biology · 4 Aug 2026 · Preprint

Glycolysis →

Cognitive function

upin mice1

1 study

Recombinant human APOE2 improves cognitive function in mice.
Animalsco-administered with ADTC54-8 weeks
Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 mice · bioRxiv : the preprint server for biology · 4 Aug 2026 · Preprint

Oxidative stress and ROS signalling

downin mouse cells1

1 study

Recombinant human APOE2 protects against oxidative stress and ROS signalling in mouse cells.
Cellsin ApoE4-knockin mouse primary neurons
Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 mice · bioRxiv : the preprint server for biology · 4 Aug 2026 · Preprint

Oxidative stress and ROS signalling →

APOE

downin mouse cells1

1 study