In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging…In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging markers and poorer late-life cognition.
Top-quartile small HDL particle counts had all-cause mortality hazard ratios of 0.79 in men and 0.77 in women compared with bottom quartiles.Top-quartile small HDL particle counts had all-cause mortality hazard ratios of 0.79 in men and 0.77 in women compared with bottom quartiles. In a preprint analyzing 47,123 men and 97,589 women from the Mexico City Prospective Study, researchers tracked 11,264 male and 15,486 female deaths…
Each kg/m² increase in fat mass index was linked to a 23% rise in serum C-reactive protein, whereas menopause stage showed no independent association.Each kg/m² increase in fat mass index was linked to a 23% rise in serum C-reactive protein, whereas menopause stage showed no independent association. In a multi-ethnic cohort of 1,681 women followed from 1996 to 2018, midlife increases in C-reactive protein (CRP) were linked to gains in…
In a study of 324,806 ICU admissions, lower arterial blood pH within 24 hours showed a stronger link to mortality in patients aged 65 and older.In a study of 324,806 ICU admissions, lower arterial blood pH within 24 hours showed a stronger link to mortality in patients aged 65 and older. In a nationwide retrospective study of 324,806 adult intensive care unit admissions in Japan, researchers examined whether patient age influences…
A cross-sectional study of 9,717 Caucasian adults aged 20 to 90 mapped age-related changes in bone, muscle, fat, and intramuscular adipose tissue.A cross-sectional study of 9,717 Caucasian adults aged 20 to 90 mapped age-related changes in bone, muscle, fat, and intramuscular adipose tissue. In a cross-sectional study of 9,717 Caucasian adults aged 20 to 90 years, researchers evaluated sex- and age-specific patterns in body…
Cancer incidence rose modestly above baseline with adjusted hazard ratios of 1.05 to 1.08, while mortality followed a J-shaped pattern across serum…Cancer incidence rose modestly above baseline with adjusted hazard ratios of 1.05 to 1.08, while mortality followed a J-shaped pattern across serum vitamin B12 strata. In a retrospective study of 3,950,497 adults across 19 countries, researchers evaluated how baseline serum vitamin B12…
In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East…In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East Asians (OR 3.14). In a study of 457,242 UK Biobank participants and 7,058 Singapore Epidemiology of Eye Diseases participants, researchers…
Frailty independently predicted mortality with an adjusted odds ratio of 8.4 in 47 older adults, whereas fracture complexity and reduction quality…Frailty independently predicted mortality with an adjusted odds ratio of 8.4 in 47 older adults, whereas fracture complexity and reduction quality predicted surgical failure. In a retrospective study of 47 patients aged 65 years and older undergoing surgery for tibial plateau fractures…
Five-year cancer-specific mortality reached 44.0% in cancer patients with dementia compared with 39.4% in matched cancer patients without dementia.Five-year cancer-specific mortality reached 44.0% in cancer patients with dementia compared with 39.4% in matched cancer patients without dementia. In a nationwide cohort of Danish cancer patients diagnosed between 1995 and 2022, researchers matched 17,425 individuals with pre-existing…
Dual vision impairment yielded a hazard ratio of 1.59 for functional-independence loss, compared with 1.39 for near-only and 1.42 for distance-only…Dual vision impairment yielded a hazard ratio of 1.59 for functional-independence loss, compared with 1.39 for near-only and 1.42 for distance-only impairment. In older adults from the English Longitudinal Study of Ageing, researchers examined how self-rated vision problems link to…
In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue…In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue attenuation generally dropped with age.
In UK Biobank, every 5 µg/m³ increment in PM2.5 carried an incident ischemic stroke hazard ratio of 1.29, reaching 1.44 alongside high genetic…In UK Biobank, every 5 µg/m³ increment in PM2.5 carried an incident ischemic stroke hazard ratio of 1.29, reaching 1.44 alongside high genetic susceptibility. In two population-based human cohorts, researchers evaluated how ambient air pollution relates to stroke risk alongside systemic…
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated…An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres. Researchers studied 80 community-dwelling older adults in Santiago, Chile, using data from the ALEXANDROS cohort.
In a scan of 442 oral prescription drugs, 218 were associated with digestive cancer risk and 28 showed an inverse association.In a scan of 442 oral prescription drugs, 218 were associated with digestive cancer risk and 28 showed an inverse association. In older adults from the SEER-Medicare database, researchers evaluated potential links between oral prescription medications and digestive cancer risk.
In 23,376 older adults tracked over nine years, trajectories ranged from persistent minimal pain in 44.9% to high increasing pain in 9.6%.In 23,376 older adults tracked over nine years, trajectories ranged from persistent minimal pain in 44.9% to high increasing pain in 9.6%. Researchers analyzed five waves of data from 23,376 Chinese adults aged 45 years and older in the China Health and Retirement Longitudinal Study…
Global cognitive aging rates showed an inverted U-shaped link with systolic pressure, peaking at 120.1 mmHg overall and 130.8 mmHg in prefrail older…Global cognitive aging rates showed an inverted U-shaped link with systolic pressure, peaking at 120.1 mmHg overall and 130.8 mmHg in prefrail older adults. Researchers analyzed 4,723 non-frail adults aged 45 and older from the China Health and Retirement Longitudinal Study tracked between…
Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2…Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors. In a retrospective study of adults aged 60 and older with type 2 diabetes, researchers compared outcomes between sodium-glucose…
Per standard-deviation increase, odds ratios for Alzheimer's disease dementia were 0.66 for midlife and 0.50 for late-life cognitive activity, but…Per standard-deviation increase, odds ratios for Alzheimer's disease dementia were 0.66 for midlife and 0.50 for late-life cognitive activity, but 0.91 for childhood activity.
Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path.Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path. In 2,476 participants from the China Multi-Ethnic Cohort study in southwestern China, researchers examined the bidirectional relationship…
Across 169 older adults followed over three years, stronger 24-hour activity rhythms tracked with better executive function and reduced risk of mild…Across 169 older adults followed over three years, stronger 24-hour activity rhythms tracked with better executive function and reduced risk of mild cognitive impairment. In 169 older adults from the BIOCARD study, researchers examined 24-hour rest-activity rhythms using repeated seven-day…
The highest arterial stiffness tertile had higher risks of sarcopenia (HR 1.56) and probable sarcopenia (HR 1.38) compared with the lowest tertile.The highest arterial stiffness tertile had higher risks of sarcopenia (HR 1.56) and probable sarcopenia (HR 1.38) compared with the lowest tertile. A prospective cohort study evaluated 32,451 UK Biobank participants who were free of probable sarcopenia and sarcopenia at baseline.
