Comparing the 75th percentile with the median of NO2 exceedance days, 14-year cognitive decline was -0.09 SD for memory and -0.10 SD for fluency.Comparing the 75th percentile with the median of NO2 exceedance days, 14-year cognitive decline was -0.09 SD for memory and -0.10 SD for fluency. In a prospective cohort study of 12,235 community-dwelling adults aged 50 and older in England, researchers examined whether annual days…
Below target cutoffs, participants with less favorable social context had cardiovascular event rates of 3.39 versus 1.68, 7.16 versus 2.05, and 8.67…Below target cutoffs, participants with less favorable social context had cardiovascular event rates of 3.39 versus 1.68, 7.16 versus 2.05, and 8.67 versus 2.34 per 1,000 person-years.
Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia.Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia. In a nationwide cohort of Korean adults undergoing major cardiac or gastrointestinal surgery, researchers evaluated whether new postoperative depression is…
Depressive symptoms occurred in 38.6% of adults with cardiometabolic multimorbidity compared with 33.0% without, yielding an adjusted hazard ratio of…Depressive symptoms occurred in 38.6% of adults with cardiometabolic multimorbidity compared with 33.0% without, yielding an adjusted hazard ratio of 1.25. In a prospective study of 10,726 Chinese adults aged 45 years and older, researchers tracked cardiometabolic conditions and depressive…
High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with…High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with low-stable symptoms. In a preprint analyzing 8,952 adults in China and 10,812 in the United States, researchers evaluated whether dynamic…
Class I obesity was associated with a 27% lower mortality risk compared with normal weight in a large U.S. study of people with incident dementia.Class I obesity was associated with a 27% lower mortality risk compared with normal weight in a large U.S. study of people with incident dementia. In a large, population-based U.S.
In 1,505,638 COPD patients, high frailty was linked to mortality hazard ratios of 2.66 under age 70 and 1.90 at 70 and older versus low-frailty older…In 1,505,638 COPD patients, high frailty was linked to mortality hazard ratios of 2.66 under age 70 and 1.90 at 70 and older versus low-frailty older peers. In a nationwide retrospective cohort of 1,505,638 South Korean patients aged 40 and older with chronic obstructive pulmonary disease…
An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter.An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter. In a study of 13,284 U.S. adults from NHANES, researchers evaluated how different iron sources relate to biological aging.
In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis.In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis. In a study of 63,083 UK Biobank participants, researchers tracked sleep parameters and incident osteoporosis over a median 7.8-year follow-up.
Standardised type 2 diabetes prevalence rose from 14.7% in 1987 to peak at 23.3% in 2009 before falling to 19.9% in 2021.Standardised type 2 diabetes prevalence rose from 14.7% in 1987 to peak at 23.3% in 2009 before falling to 19.9% in 2021. In a nationwide study of adults aged 25 to 74 years in Mauritius, researchers tracked metabolic trends across seven population surveys between 1987 and 2021, totaling…
In longitudinal Add Health data, cumulative exposure across development outdid recency and timing in predicting allostatic load, while adolescent peer…In longitudinal Add Health data, cumulative exposure across development outdid recency and timing in predicting allostatic load, while adolescent peer ties showed promotive benefits.
Comorbidity was linked to hospital disability in nonfrail patients (OR 1.44), but the association attenuated with mild frailty (OR 1.11) and…Comorbidity was linked to hospital disability in nonfrail patients (OR 1.44), but the association attenuated with mild frailty (OR 1.11) and disappeared in frail adults (OR 0.98).
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival. In human participants from the National Health and Nutrition Examination Survey (NHANES) and the UK Biobank, researchers examined whether biological age tracks…
All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04)…All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04) versus neither. In an observational study of 4,754 postmenopausal U.S.
A Global Burden of Disease analysis across 204 countries estimated 56.0 million prevalent heart failure cases in 2023, with rates generally increasing…A Global Burden of Disease analysis across 204 countries estimated 56.0 million prevalent heart failure cases in 2023, with rates generally increasing with age. In a cross-sectional study of human populations across 204 countries and territories, researchers evaluated the global burden of…
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk…In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14). In older human adults from the UK Biobank and the Atherosclerosis Risk in Communities study, researchers evaluated whether…
Anticholinergic use was associated with higher incident dementia risk compared with β3-agonist use (hazard ratio, 1.49; 95% CI, 1.04–2.13).Anticholinergic use was associated with higher incident dementia risk compared with β3-agonist use (hazard ratio, 1.49; 95% CI, 1.04–2.13). In a retrospective study of women aged 65 to 84 years in Japan, researchers compared long-term outcomes between two classes of overactive bladder…
In a meta-analysis of 18,551 older adults across six countries, widowed individuals scored lower in memory (β = -0.07) and executive function (β =…In a meta-analysis of 18,551 older adults across six countries, widowed individuals scored lower in memory (β = -0.07) and executive function (β = -0.08). Researchers analyzed data from 18,551 older adults across six prospective cohort studies in the United States, England, Mexico, China…
In adults aged 60 to 69, low global cognition carried a stroke hazard ratio of 1.86 compared with the highest tertile over 12.3 years.In adults aged 60 to 69, low global cognition carried a stroke hazard ratio of 1.86 compared with the highest tertile over 12.3 years. In a cohort of 4,912 Swedish adults aged 60 and older, lower cognitive performance was linked to an increased risk of first-time stroke over an average…
Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05).Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05). In a bidirectional two-sample Mendelian randomization study of more than 51,000 Europeans, researchers tested whether cortical thickness or…
Frailty scores rose 0.63 points per year before hypertension diagnosis and 1.09 points after, outpacing matched controls across eight years before and…Frailty scores rose 0.63 points per year before hypertension diagnosis and 1.09 points after, outpacing matched controls across eight years before and after diagnosis. In a study of 21,418 older adults followed across 14 countries for up to 18 years, individuals who developed hypertension…
Older adults had an overall dementia hazard ratio of 1.51 after documented infection compared with matched uninfected peers across up to six years of…Older adults had an overall dementia hazard ratio of 1.51 after documented infection compared with matched uninfected peers across up to six years of follow-up. In a retrospective study of 899,490 propensity-matched older adults with type 2 diabetes, documented COVID-19 was associated with…
The highest quartile of moderate activity was tied to a hazard ratio of 0.41 compared with the lowest quartile in 47,861 hypertensive adults.The highest quartile of moderate activity was tied to a hazard ratio of 0.41 compared with the lowest quartile in 47,861 hypertensive adults. Among 47,861 UK Biobank participants with hypertension who wore wrist accelerometers, 574 developed dementia over a median follow-up of 8.1 years.
