In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed. In Klotho heterozygous knockout mice, reduced Klotho levels led to hyperkalemia and decreased urinary potassium excretion.
Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to…Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to promote proliferation. In cultured breast and lung cells and mouse xenografts, researchers used a microenvironment microarray platform to…
In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in…In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in men and women. In a cohort of aging adults, researchers tracked how salivary sex-steroid hormones relate to cerebellar structure over one…
In mice exposed to ionizing radiation, deleting Brn2 altered DNA damage responses and triggered permanent hair depigmentation linked to melanocyte…In mice exposed to ionizing radiation, deleting Brn2 altered DNA damage responses and triggered permanent hair depigmentation linked to melanocyte stem cell depletion. In mice and human cell datasets, researchers investigated how the transcription factor BRN2 preserves adult melanocyte…
In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered…In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers. In primary mouse cortical neurons and human induced pluripotent stem cell-derived forebrain neurons, researchers assessed…
People with intramuscular fat fractions above 10% showed significantly lower paraspinal muscle mass and strength than those with levels below 5%.People with intramuscular fat fractions above 10% showed significantly lower paraspinal muscle mass and strength than those with levels below 5%. In people with spinal sarcopenia, researchers found that the intramuscular fat fraction, rather than perimuscular fat fraction, was an…
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…
Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their…Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling. In monogamous prairie voles, expressing dementia-linked tau P301L in the hypothalamus disrupts selective social bonds…
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not…In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females. Researchers analyzed purified elastin networks from 17 human thoracic aortas from donors aged 26 to 92 years, including nine males…
In 46 older and 51 younger adults, altered integrity in two social brain tracts partly mediated age-related vulnerability to email phishing.In 46 older and 51 younger adults, altered integrity in two social brain tracts partly mediated age-related vulnerability to email phishing. In a study of 51 younger adults and 46 cognitively healthy older adults, researchers examined how age-related changes in brain white matter relate to…
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality. In mice, deficiency of the renal proximal tubule protein TMEM174 significantly shortened lifespan compared to wild-type…
Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men.Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men. In six older men, researchers analyzed somatic mitochondrial DNA variants from paired skin biopsies taken from photoexposed forearms and photoprotected buttocks.
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects. In a new mouse model of cesarean section scar defects, researchers investigated the mechanisms that disrupt uterine healing.
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice. In experiments using cultured myoblasts, mice, and human tissues, researchers investigated how calcium overload hinders skeletal muscle regeneration.
Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a…Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a century.
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures. In cell culture experiments using primary muscle cells from young (15–25 years) and aged (60–86 years) human donors, researchers evaluated how aging alters the…
