Synapse
Cell component10 papersGO 0045202
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Latest
10RAS/MAPK overactivation drives motor axon loss in flies
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.
App knock-in mice display age-dependent Alzheimer's pathology
In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and…In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.
Voluntary running shows limited neuroprotection in mice
In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology…In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.
Microglial depletion triggers distinct molecular responses in male and female aged mouse brains
Aged male mice showed far larger proteomic shifts than females following microglial removal, including alterations in synaptic and mitochondrial…Aged male mice showed far larger proteomic shifts than females following microglial removal, including alterations in synaptic and mitochondrial proteins.
Rapid auditory readout tracks nerve loss in gerbils
A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.
Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in…Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Ramadan fasting is linked to respiratory sarcopenia in older men
In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both…In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both sexes.
Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.