Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan…Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan compared to group-housed flies.
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs. In mice, age-related fertility decline involves defective chromatin maintenance, according to a new preprint.
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity…Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age. In Caenorhabditis elegans, researchers identified the nuclear receptor SEX-1 as a functional counterpart to mammalian…
Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells…Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized fibroinflammation.
Each kg/m² increase in fat mass index was linked to a 23% rise in serum C-reactive protein, whereas menopause stage showed no independent association.Each kg/m² increase in fat mass index was linked to a 23% rise in serum C-reactive protein, whereas menopause stage showed no independent association. In a multi-ethnic cohort of 1,681 women followed from 1996 to 2018, midlife increases in C-reactive protein (CRP) were linked to gains in…
The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after…The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure. In human skin tissue samples from 20 donors, researchers established an ex vivo platform that preserved native…
Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6…Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6 pathways that induced senescence-linked responses in vitro.
Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip…Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip fractures (OR 0.68). Researchers analyzed genetic and health records from 401,983 unrelated UK Biobank participants to test how incretin…
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits. In the nematode Caenorhabditis elegans, researchers found that alpha-synuclein progressively alters lipid metabolism during aging.
In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East…In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East Asians (OR 3.14). In a study of 457,242 UK Biobank participants and 7,058 Singapore Epidemiology of Eye Diseases participants, researchers…
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models. Researchers analyzed gene expression in inner ear pericytes from young and aged mice.
