Electronic cigarette aerosol

2 papers5 findings

2 independent labs in 1 country

Funder: National Institutes of Health

Animals1
Cells1

Outcomes

4

Cellular senescence

upin human cells1upin rats1

2 studies

Electronic cigarette aerosol induces cellular senescence in human cells.
“SenMayo analysis showed cell type-specific patterns of senescence-associated gene set enrichment, with the strongest signal in club cells”
Cellsacute exposure, strongest signal in club cellsairway epithelium30 min exposure, analyzed 24 h later
Disease-dependent airway epithelial responses to acute electronic cigarette aerosol exposure: a pilot single-cell analysis
Toxicological sciences : an official journal of the Society of Toxicology5 Jun 2026
Electronic cigarette aerosol induces cellular senescence in rats.
“consistent with redox imbalance, neuroinflammation, and advancing cellular senescence.”
Animalsmaternal vaping / in-utero Ecig exposurebrain
Nicotine Influence on Vascular and Neurocognitive Function with In-utero Electronic Cigarette Exposure
bioRxiv : the preprint server for biology17 Feb 2025Preprint

More on Cellular senescence

CDKN1A

upin human cells1

1 study

Electronic cigarette aerosol increases CDKN1A in human cells.
“increased CDKN2A and CDKN1A expression in asthma-derived epithelial populations”
Cellsin asthma-derived epithelial populations following acute e-cig aerosol exposureairway epithelium30 min exposure, analyzed 24 h later
Disease-dependent airway epithelial responses to acute electronic cigarette aerosol exposure: a pilot single-cell analysis
Toxicological sciences : an official journal of the Society of Toxicology5 Jun 2026

CDKN2A

upin human cells1

1 study

Electronic cigarette aerosol increases CDKN2A in human cells.
“increased CDKN2A and CDKN1A expression in asthma-derived epithelial populations”
Cellsin asthma-derived epithelial populations following acute e-cig aerosol exposureairway epithelium30 min exposure, analyzed 24 h later
Disease-dependent airway epithelial responses to acute electronic cigarette aerosol exposure: a pilot single-cell analysis
Toxicological sciences : an official journal of the Society of Toxicology5 Jun 2026

Cerebrovascular function

downin rats1

1 study

Electronic cigarette aerosol impairs cerebrovascular function in rats.
“offspring with in-utero exposure (at 5w and 30w Ecig conditions) exhibited impaired middle cerebral artery (MCA) reactivity.”
Animalsin-utero exposure (at 5w and 30w Ecig conditions)middle cerebral artery
Nicotine Influence on Vascular and Neurocognitive Function with In-utero Electronic Cigarette Exposure
bioRxiv : the preprint server for biology17 Feb 2025Preprint

Latest

1 in 12 months

Toxicological Sciences5 Jun

Disease-dependent airway epithelial responses to acute electronic cigarette aerosol exposure: a pilot single-cell analysis

Experiments in human cellsImmune response

bioRxiv3 Mar

Nicotine Influence on Vascular and Neurocognitive Function with In-utero Electronic Cigarette Exposure

Preprint: experiments in ratsMechanisms