Blue light
Intervention2 papers8 findings
A cell study in human dermal fibroblasts reports that blue light activates NF-κB signalling and increases DNA double-strand breaks, senescence-associated beta-galactosidase at 25 J/cm² and CDKN1A at 50 J/cm².
- Animals1
- Cells1
Outcomes
8NF-κB signalling
upin human cells1Very low certainty
1 study
NF-κB signalling
upin human cells1Very low certainty
Blue light activates NF-κB signalling in human cells.
Cellshuman dermal fibroblasts
Blue Light Exposure Induces Changes Associated With Senescence and Skin Aging in Human Dermal Fibroblasts · FASEB bioAdvances · 22 Sep 2026
Senescence-associated beta-galactosidase
upin human cells1Very low certainty
1 study
Senescence-associated beta-galactosidase
upin human cells1Very low certainty
Blue light increases senescence-associated beta-galactosidase in human cells.
Cellshuman dermal fibroblasts25 J/cm2
Blue Light Exposure Induces Changes Associated With Senescence and Skin Aging in Human Dermal Fibroblasts · FASEB bioAdvances · 22 Sep 2026
CDKN1A
upin human cells1Very low certainty
1 study
CDKN1A
upin human cells1Very low certainty
Blue light increases CDKN1A in human cells (15-fold increase).
Cellshuman dermal fibroblasts50 J/cm2
Blue Light Exposure Induces Changes Associated With Senescence and Skin Aging in Human Dermal Fibroblasts · FASEB bioAdvances · 22 Sep 2026
DNA double-strand breaks
upin human cells1Very low certainty
1 study
DNA double-strand breaks
upin human cells1Very low certainty
Blue light increases DNA double-strand breaks in human cells.
Cellshuman dermal fibroblasts
Blue Light Exposure Induces Changes Associated With Senescence and Skin Aging in Human Dermal Fibroblasts · FASEB bioAdvances · 22 Sep 2026
UCP1
no changein mice1Very low certainty
1 study
UCP1
no changein mice1Very low certainty
Blue light has no effect on UCP1 in mice.
“brown adipose tissue weight and UCP1 protein levels remained unchanged”
Animalsbrown adipose tissue13 mW/cm240 weeks
The Hidden Cost of Blue Light: Multiorgan Pathology Induced by LED Exposure in Mice · bioRxiv · 16 Sep 2026 · Preprint
White adipose tissue mass
upin mice1Very low certainty
1 study
White adipose tissue mass
upin mice1Very low certainty
Blue light increases white adipose tissue mass in mice.
“White adipose tissue mass increased”
Animals13 mW/cm240 weeks
The Hidden Cost of Blue Light: Multiorgan Pathology Induced by LED Exposure in Mice · bioRxiv · 16 Sep 2026 · Preprint
Relative organ weight
downin mice1−10%Very low certainty
1 study
Relative organ weight
downin mice1−10%Very low certainty
Blue light decreases relative organ weight in mice (~10%).
“Relative organ weights (heart, liver, kidney, testis) were each reduced by ~10%”
Animals13 mW/cm240 weeks
The Hidden Cost of Blue Light: Multiorgan Pathology Induced by LED Exposure in Mice · bioRxiv · 16 Sep 2026 · Preprint
Body weight
upin mice1Very low certainty
1 study
Body weight
upin mice1Very low certainty
Blue light increases body weight in mice.
“Mice exhibited progressive weight gain despite reduced food intake”
Animals13 mW/cm240 weeks
The Hidden Cost of Blue Light: Multiorgan Pathology Induced by LED Exposure in Mice · bioRxiv · 16 Sep 2026 · Preprint