Preoperative Frailty-Inflammation Phenotypes and Early Functional and Patient-Reported Recovery After Head-and-Neck Oncologic Reconstruction: An Exploratory Prospective Single-Center Cohort Study
Journal of Clinical Medicine
Abstract
Background/Objectives: Early recovery after major head-and-neck reconstruction is not determined by flap survival alone. This exploratory study examined whether preoperative frailty-inflammatory phenotypes are associated with delayed swallowing recovery, persistent nutritional dependence, and poorer quality of life at 12 weeks.
- Head-and-neck oncologic reconstruction
- Inflammation
- Head and neck cancer
- 5-item modified frailty index
- C-reactive protein-to-albumin ratio
- Humans
The paper
Sonia-Roxana Burtic, Bogdan Florin Căpăstraru, Panche Taskov, Adelina Maria Jianu
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Tudorel Mihoc, Codrina Mihaela Levai, Andreea Mihaela Kiș, Roxana Manuela Fericean, Mihaela Iuliana Ciortan, Daniel Laurențiu Pop,Victor Babeș University of Medicine and Pharmacy Timișoara
Journal of Clinical Medicine · 14 Sep 2026 · CC BY