Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological…Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity…Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35. In a study of 706 human trauma patients enrolled in emergency departments, researchers evaluated biological age…
In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across…In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across adulthood. In an observational study of 400,594 UK Biobank participants, researchers developed MetScore2, a biological aging metric derived…
TyG-WHtR tracked incident cardiometabolic multimorbidity with a hazard ratio of 3.18 in a Chinese cohort and showed consistent performance alongside…TyG-WHtR tracked incident cardiometabolic multimorbidity with a hazard ratio of 3.18 in a Chinese cohort and showed consistent performance alongside ICMRS in English adults. In a preprint analyzing older adults from China and the United Kingdom, researchers tested whether composite…
In 8.8 million surgical hospitalizations, a 10-point frailty score rise increased mortality 22.8-fold, while rheumatoid arthritis was linked only to…In 8.8 million surgical hospitalizations, a 10-point frailty score rise increased mortality 22.8-fold, while rheumatoid arthritis was linked only to greater discharge resource needs.
In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63…In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years. In 9,008 older adults from the Health and Retirement Study, researchers measured 24 peripheral immune cell subsets using flow…
In Hispanic and Latino adults, a newly identified APOE cluster raised the odds of significant cognitive decline with an odds ratio of 1.47 over the…In Hispanic and Latino adults, a newly identified APOE cluster raised the odds of significant cognitive decline with an odds ratio of 1.47 over the main cluster. In a study of Hispanic and Latino adults, researchers identified a novel genetic profile in the APOE region that associates more…
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts. Researchers evaluated 16,215 UK Biobank participants who were dementia-free at baseline over a median follow-up of 10.08 years.
In 188 individuals with chronic stroke, regional deviations from normative brain aging in the undamaged hemisphere accounted for aphasia severity and…In 188 individuals with chronic stroke, regional deviations from normative brain aging in the undamaged hemisphere accounted for aphasia severity and predicted post-therapy recovery.
In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among…In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers. In human cohorts, researchers evaluated gene-specific clonal hematopoiesis of indeterminate potential (CHIP) across 19 common solid…
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two…Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts. Researchers analyzed prospective data from 3,947 Chinese and 1,431 English middle-aged and older adults to examine how combined…
In 1,780 Latinos, diagnostic AUCs reached 0.70 to 0.75 for mild cognitive impairment and 0.83 to 0.84 for dementia across Spanish and English testing.In 1,780 Latinos, diagnostic AUCs reached 0.70 to 0.75 for mild cognitive impairment and 0.83 to 0.84 for dementia across Spanish and English testing. In a cross-sectional study of 1,780 English- and Spanish-speaking Latinos, researchers established revised cutoff scores for the Montreal…
In 2,685 adults aged 65 and older across five nations, the protocol supported five distinct cognitive domains and a general performance factor…In 2,685 adults aged 65 and older across five nations, the protocol supported five distinct cognitive domains and a general performance factor associated with age. The study evaluated 2,685 adults aged 65 and older from the Czech Republic, Denmark, France, Germany, and Italy to examine the…
Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but…Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder risk. In human participants from the UK Biobank and FinnGen cohorts, researchers evaluated how a composite measure of…
Participants in the highest tertile of the combined CTI-CVAI index had a 2.14-fold higher stroke risk than those in the lowest tertile.Participants in the highest tertile of the combined CTI-CVAI index had a 2.14-fold higher stroke risk than those in the lowest tertile. In a prospective cohort of 8,267 stroke-free adults aged 45 and older from the China Health and Retirement Longitudinal Study, researchers tracked 816…
