Litevax adjuvant

Intervention

1 paper5 findings

  • 1 lab in 1 country
  • Funders: European Commission and 1 more
  • Human trial1

Outcomes

5

Age-related differences in early immune responses

downin humans1

1 study
  1. Litevax adjuvant decreases age-related differences in early immune responses in humans.

    “LVA reduced age-related differences in early immune responses”

    Human trialreceiving a quadrivalent influenza vaccine

    LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

    Research Square3 Aug 2026Preprint

Overall antibody magnitude

no changein humans1

1 study
  1. Litevax adjuvant has no effect on overall antibody magnitude in humans.

    “without affecting overall antibody magnitude”

    Human trialreceiving a quadrivalent influenza vaccine

    LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

    Research Square3 Aug 2026Preprint

More on Overall antibody magnitude

IgG-producing plasmablasts

upin humans1

1 study
  1. Litevax adjuvant increases IgG-producing plasmablasts in humans.

    “increased IgG-producing plasmablast frequencies”

    Human trialreceiving a quadrivalent influenza vaccine

    LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

    Research Square3 Aug 2026Preprint

More on IgG-producing plasmablasts

IgG3

upin humans1

1 study
  1. Litevax adjuvant increases IgG3 in humans.

    “accelerated early IgG3 antibody responses”

    Human trialreceiving a quadrivalent influenza vaccine

    LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

    Research Square3 Aug 2026Preprint

More on IgG3

Type I interferon signalling

upin humans1

1 study
  1. Litevax adjuvant activates type I interferon signalling in humans.

    “LVA induced a rapid, transient interferon-driven innate response, primarily in monocytes”

    Human trialreceiving a quadrivalent influenza vaccine

    LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

    Research Square3 Aug 2026Preprint

More on Type I interferon signalling

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