Glucocorticoids

Intervention4 papers5 findings

  • Humans2

Outcomes

3

Delayed visual-spatial performance

upin rats1Low certainty

1 study
  1. Glucocorticoids induce delayed visual-spatial performance in rats.

    Animalsglucocorticoid-induced low-BMD

    Decoding the Bone-Eye Axis: Machine Learning for Age-Related Macular Degeneration Risk Prediction · Cyborg and bionic systems (Washington, D.C.) · 14 Sep 2026

FI23

no changein humans1Very low certainty

1 study
  1. Glucocorticoids have no effect on FI23 in humans (β=0.0043 (95% CI -0.0018 to 0.0104; P=0.167)).

    Humansall-indicationtwo-yearn = 23,460

    Oral systemic glucocorticoid exposure and next-year frailty-deficit accumulation in US adults: a longitudinal MEPS study · Authorea Preprints · 12 Sep 2026 · Preprint

FI23 →

Frailty

upin humans1

1 study
  1. Glucocorticoids increase frailty in humans.

    Review

    Frailty in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: Current evidence and knowledge gaps · Therapeutic advances in musculoskeletal disease · 22 Aug 2026

Associations

2

Osteoporosis

upin humans1Very low certainty

1 study
  1. Glucocorticoids raise the risk of osteoporosis in humans.

    Humansvirologically suppressed PLWHmales

    Sex-specific prevalence and factors associated with osteoporosis among older people living with HIV under long-term virological suppression in western China: A retrospective cross-sectional study · Research Square · 15 Sep 2026 · Preprint

Osteoporosis →

Bone fracture

upin humans1

1 study
  1. Glucocorticoids raise the risk of bone fracture in humans.

    “Systemic glucocorticoids constituted the clearest modifiable treatment-related risk, but did not fully explain the association.”

    Reviewin atopic dermatitissystemic

    Atopic Dermatitis and Bone Fragility: Osteoimmunological Pathways, Therapeutic Paradoxes, and Risk-Adapted Screening Across the Lifespan · Preprints.org · 3 Sep 2026 · Preprint

Bone fracture →

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