Age

1. Age decreases cortical responses signaling global prediction errors in humans.

   “Linear age-related decline can be seen in both cortical responses signaling local prediction errors (including the mismatch negativity and P3a) and global prediction errors (including the frontocentral negativity and P3b).”

   Humansn = 406

   Neural Correlates of Local and Global Prediction Errors Show Similar Linear Age-related Decline But Differential Associations with Working Memory

   Journal of cognitive neuroscience·23 Mar 2026

1. Age decreases cortical responses signaling local prediction errors in humans.

   “Linear age-related decline can be seen in both cortical responses signaling local prediction errors (including the mismatch negativity and P3a) and global prediction errors (including the frontocentral negativity and P3b).”

   Humansn = 406

   Neural Correlates of Local and Global Prediction Errors Show Similar Linear Age-related Decline But Differential Associations with Working Memory

   Journal of cognitive neuroscience·23 Mar 2026

1. Age increases neural differentiation of rumination and worry in humans.

   “neural differentiation of rumination and worry increased with age.”

   Humans

   Age differences in neural discriminability of rumination and worry

   Communications biology·8 Jan 2026

1. Age decreases event-related potential amplitude in humans.

   “Amplitudes increased on short timescales (seconds) but declined over longer timescales (minutes) and with advancing age.”

   Humans

   Predictive Processing Over the Course of Aging: Multiple Timescales of Effective Connectivity

   The European journal of neuroscience·1 Jan 2026

More on Event-related potential amplitude

1. Age impairs cognitive function in humans (rho = -0.32, p < 0.01).

   “FAB total scores were inversely associated with age ( rho = ‐0.32; p < 0.01)”

   Humansin cognitively unimpaired controlsn = 71

   The Frontal Assessment Battery in older multilingual Kenyan adults

   AAIC 2025 abstract·25 Dec 2025

1. Age increases frailty in humans.

   “FI values increased with age and were consistently higher in women than in men, indicating that older women had higher levels of frailty.”

   Humans2 yearsn = 9,093

   Two-year evolution of frailty status and predictive factors in Chinese older adults: a national longitudinal study

   BMC geriatrics·17 Nov 2025

1. Age impairs verbal associative memory in humans.

   “Age, biological sex, and educational attainment are all significantly associated with PAL performance in both Hispanic cohorts, regardless of the participant's FSL.”

   Humansin Hispanic individuals

   The Association of Age, Sex, and Educational Attainment on Verbal Associative Memory Performance among Hispanic Individuals with Differing First Spoken Language

   Gerontology·31 Oct 2025

1. Age decreases female sexual function in humans.

   “The mean scores for the MFSQ sexual interest and MFSQ partner satisfaction domains, the total MFSQ, and the total DIVA decreased as women got older.”

   Humansas women got olderfemales

   The association between day-to-day impact of vaginal aging and female sexual function

   Climacteric : the journal of the International Menopause Society·10 Sep 2025

1. Age decreases handgrip strength in humans.

   “For both men and women, handgrip strength decreased with increasing age.”

   Humans

   ASSOCIATION OF CUMULATIVE RISK FACTORS AND HANDGRIP STRENGTH AMONG COMMUNITY-DWELLING OLDER ADULTS IN INDIA

   GSA 2024 abstract·31 Dec 2024

1. Age decreases physical activity in humans (5% decrease in odds, OR = 0.96, p = 0.014).

   “Every unit increase in age and HbA1c decreased the odds of Black women meeting the PA guidelines by 5% and 27.6% (OR = 0.96, p = 0.014”

   Humanswith cardiovascular diseasefemales

   BIOPSYCHOSOCIAL DETERMINANTS OF PHYSICAL ACTIVITY IN BLACK WOMEN WITH CARDIOVASCULAR DISEASE

   GSA 2024 abstract·31 Dec 2024

More on Physical activity

1. Age is associated with sarcopenia in humans (OR 1.51 per 5-year increase, 95% CI 1.11-2.12).

   “older age (OR 1.51 per 5-year increase; 95% CI 1.11-2.12)”

   Humansin adults with hip osteoarthritis undergoing primary THAn = 203

   Prevalence of Sarcopenia in Patients with Hip Osteoarthritis Undergoing Total Hip Arthroplasty: A Cross-Sectional Study Based on EWGSOP2 Criteria

   Journal of clinical medicine·4 Aug 2026

2. Age is associated with sarcopenia in humans (18.7%).

   “The prevalence of sarcopenia in all participants was 18.7% and increased with age.”

   Humanselderly diabetes patientsn = 267

   Importance of physical evaluation using skeletal muscle mass index and body fat percentage to prevent sarcopenia in elderly Japanese diabetes patients

   Journal of diabetes investigation·8 Sep 2018

More on Sarcopenia

1. Age raises the risk of mortality in humans (HR 1.049, 95% CI 1.020-1.078, p < 0.001).

   “age (HR: 1.049 [95%CI 1.020-1.078]; p < 0.001) were independently associated with mortality.”

   Humanshemodialysis patients

   Prognostic value of functional capacity assessed by the Glittre Activities of Daily Living test in hemodialysis patients: a prospective observational study

   Jornal brasileiro de nefrologia·1 Jan 2026

2. Age predicts mortality in humans (HR 1.16, 95% CI 1.07-1.3).

   “Mortality was predicted by age (hazard ratio 1.16 for each year increase beyond age 75 years, 95% CI 1.07-1.3, P=.0003)”

   Humansn = 404

   Survival of elderly persons undergoing colonoscopy: implications for colorectal cancer screening and surveillance

   Gastrointestinal endoscopy·1 Sep 2007

1. Age raises the risk of pulmonary mortality in humans (HR 1.11, 95% CI 1.09-1.13).

   “age (hazard ratio [HR], 1.11; 95% CI, 1.09-1.13)”

   Humansin patients with obstructive sleep apneamedian 8.6 yearsn = 4,368

   Risk factors for pulmonary mortality in patients with obstructive sleep apnea: a competing risk analysis integrating Cox regression, random survival forests, and unsupervised clustering

   Polish archives of internal medicine·2 Oct 2026

1. Age is associated with 1-year mortality in humans (adjusted odds ratio 1.19, 95% confidence interval 1.03-1.47).

   “age (adjusted odds ratio 1.19, 95% confidence interval 1.03-1.47; p = 0.010)”

   Humansfragility fracture of the pelvis1-yearn = 46

   Association between the updated Charlson comorbidity index and 1-year mortality after fragility fracture of the pelvis: A prospective observational study

   Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·29 Sep 2026

1. Age is associated with mammogram recency in humans (OR = 1.09, 95% CI = 1.06, 1.12).

   “having a mammogram in the last two years was associated with age (OR = 1.09, 95% CI = 1.06, 1.12)”

   Humansmultivariable logistic regressionfemalesn = 186

   Correlates of Mammogram Screening Among Brazilian Immigrant Women in the United States: Analysis of 2020 Cross-Sectional Survey Data

   Journal of racial and ethnic health disparities·17 Sep 2026

1. Age is associated with emergency department encounter in humans (34.7% to 39.4%).

   “This proportion increased with age: (≥65 to <75, 34.7%; ≥75 to <85, 36.8%; ≥85, 39.4%).”

   Humansprior to hip fracture12 months

   Emergency Department Encounters Preceding Hip Fracture in Older Adults: A Window for Future Risk Identification

   Journal of the American College of Emergency Physicians open·3 Sep 2026

1. Age is associated with emotion prosody recognition in humans.

   “age, sex, education, hearing problems, subjective cognitive complaints and the number of comorbidities were associated with performance”

   Humansn = 2,858

   Demographic and clinical influences on emotion prosody recognition

   Frontiers in psychology·25 Aug 2026

1. Age predicts ICU mortality in humans (aOR 1.05).

   “Logistic regression identified age (adjusted odds ratio [aOR], 1.05)”

   Humans

   Admission characteristics and factors associated with outcomes in elderly patients aged 75 years and older in a level 3 ICU in Nepal: a 4-year registry-based retrospective study

   Acute and critical care·19 Aug 2026

1. Age is associated with self-reported visual difficulty in humans (OR 1.07, 95% CI 1.06-1.09).

   “Increasing age was associated with higher odds of reporting "some difficulty" seeing (OR 1.07, 95% CI 1.06-1.09).”

   Humansfemales

   Seeing Inequalities: Self-Reported Visual Difficulty and Eye Care Utilization Among Women in Malawi, a Secondary Analysis of the 2024 Demographic and Health Survey Data

   Vision (Basel, Switzerland)·14 Aug 2026

1. Age predicts postoperative intensive care unit admission in humans (OR 1.052, 95% CI 1.009-1.096).

   “Age (OR 1.052, 95% CI 1.009-1.096; p = 0.017)”

   Humansgeriatric hip fracture surgeryn = 243

   Comparative Analysis of the ASA-PS Score and Clinical Frailty Scale in Predicting Postoperative Intensive Care Unit Requirement in Geriatric Hip Fracture Surgery: A Retrospective Evaluation

   Journal of clinical medicine·13 Aug 2026