Biological-age acceleration

1. Loneliness increases biological-age acceleration in humans (b = 3.832 (95% CI 0.247, 7.417)).

   Humans

   Social isolation, loneliness, and biological aging acceleration · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 27 Aug 2026

Loneliness →

1. Biological-age acceleration mediates dementia in humans (HR 1.0062, 95% CI 1.0002-1.0125; mediated proportion 3.63%).

   Humanschildhood/adolescence smokingn = 285,009

   Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Dementia →

1. Biological-age acceleration mediates cardiometabolic multimorbidity in humans (5.2% to 11.1% proportion mediated, P <= 0.028).

   Humansassociation between CircS and incident diabetes, stroke, and CMM

   Circadian Syndrome and Incident Cardiometabolic Multimorbidity: The Mediating Role of Biological Age Acceleration in the CHARLS Cohort · Research Square · 10 Sep 2026 · Preprint

Cardiometabolic multimorbidity →

1. Biological-age acceleration mediates mortality in humans.

   Humansassociation between social isolation, loneliness, and mortality

   Social isolation, loneliness, and biological aging acceleration · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 27 Aug 2026

1. Biological-age acceleration raises the risk of premature mortality in humans (HR = 2.39, 95% CI: 1.56-3.66).

   Humanspatients with MASLDn = 3,849

   Association between biological aging and premature mortality among patients with metabolic dysfunction-associated steatotic liver disease · Archives of gerontology and geriatrics · 6 Sep 2026

1. Biological-age acceleration raises the risk of metabolic dysfunction-associated steatotic liver disease in humans (OR = 2.13, 95% CI: 1.82-2.50).

   Humansall participantsn = 10,933

   Association between biological aging and premature mortality among patients with metabolic dysfunction-associated steatotic liver disease · Archives of gerontology and geriatrics · 6 Sep 2026

Metabolic dysfunction-associated steatotic liver disease →

1. Infection is associated with biological-age acceleration in humans (β = 0.67, 95% CI: 0.04-1.31).

   Humansfrequent infection trajectory vs infrequent groupn = 7,614

   Longitudinal infection trajectories and biological aging acceleration in adults: a prospective cohort study · GeroScience · 5 Sep 2026

Infection →

1. Obesity is associated with biological-age acceleration in humans.

   Humansin overweight/obese phenotypes

   A Scalable Biological Clock for Metabolic Disease Prediction from the Phenome India Cohort · medRxiv · 3 Sep 2026 · Preprint

Obesity →

1. Loneliness is associated with biological-age acceleration in humans (b = 0.15 (95% CI 0.12, 0.18)).

   Humansn = 309,746

   Social isolation, loneliness, and biological aging acceleration · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 27 Aug 2026

Loneliness →

1. Social isolation is associated with biological-age acceleration in humans (b = 0.17 (95% CI 0.14, 0.19)).

   Humansn = 309,746

   Social isolation, loneliness, and biological aging acceleration · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 27 Aug 2026

Social isolation →

1. Cell cycle regulation is associated with biological-age acceleration in humans.

   Humansin a tissue-specific manner

   Replicative history as a major determinant of epigenetic noise across human tissues · bioRxiv · 24 Aug 2026 · Preprint

Cell cycle regulation →