Hearing loss
Disease5 papers5 findingsMeSH D034381
- Human trial1
- Humans3
- Animals1
Upstream
2SLC25A33
downin mice1
1 study
SLC25A33
downin mice1
SLC25A33 protects against hearing loss in mice.
“suppression of IGF-1 or SLC25A33 activated TGF-β/Smad2 signaling in the stria vascularis, disrupted BLB ultrastructure, and exacerbated hearing loss.”
Animalscochlea
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
IGF1
downin mice1
1 study
IGF1
downin mice1
IGF1 protects against hearing loss in mice.
“suppression of IGF-1 or SLC25A33 activated TGF-β/Smad2 signaling in the stria vascularis, disrupted BLB ultrastructure, and exacerbated hearing loss.”
Animalscochlea
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Associations
3Hearcheck
no changein humans1Low certainty
1 study
Hearcheck
no changein humans1Low certainty
Hearcheck is associated with hearing loss in humans (54.8% vs 54.5%, P = .82).
Humansn = 12,756
Hearing Loss Prevalence Among Older US Adults: HRS 2016 to 2018 Hearing Screener Data · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 29 Sep 2026
Prolonged working hours
upin humans1OR 4.15Low certainty
1 study
Prolonged working hours
upin humans1OR 4.15Low certainty
Prolonged working hours raise the risk of hearing loss in humans (adjusted OR = 4.15, 95% CI: 1.18-14.60).
“working 50-60 h per week (adjusted OR = 4.15, 95% CI: 1.18-14.60)”
Humansadjusted50-60 h per weekn = 93
Occupational Hearing Loss in the Intensive Care Unit: A Comparative Study Between ICU and Non-ICU Nursing Staff · Nursing in critical care · 26 Sep 2026
Intensive care unit environment
upin humans1OR 2.82Low certainty
1 study
Intensive care unit environment
upin humans1OR 2.82Low certainty
Intensive care unit environment raises the risk of hearing loss in humans (adjusted OR = 2.82, 95% CI: 1.25-6.35).
“Working in ICU environments (adjusted OR = 2.82, 95% CI: 1.25-6.35)”
Humansadjustedn = 93
Occupational Hearing Loss in the Intensive Care Unit: A Comparative Study Between ICU and Non-ICU Nursing Staff · Nursing in critical care · 26 Sep 2026
Latest
14Auditory nerve myelin degeneration defines a subtype of age-related hearing loss
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard…Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient…Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Association between presbycusis and cognitive function: contributing factors in older adult
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.
Hearing Loss Prevalence Among Older US Adults: HRS 2016 to 2018 Hearing Screener Data
Hearing aids did not cut dementia conversion in older adults
Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.