OSKM
Intervention1 paper4 findings
- Animals1
Outcomes
4Liver regeneration
upin animals1Very low certainty
1 study
Liver regeneration
upin animals1Very low certainty
OSKM improves liver regeneration.
Animalsafter acetaminophen-induced injurylipid nanoparticle mRNA
RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026
Sox9+ LPLC-like cells
upin animals1Very low certainty
1 study
Sox9+ LPLC-like cells
upin animals1Very low certainty
OSKM induces Sox9+ LPLC-like cells.
Animalslipid nanoparticle mRNA
RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026
Hepatocyte dedifferentiation
upin animals1Very low certainty
1 study
Hepatocyte dedifferentiation
upin animals1Very low certainty
OSKM induces hepatocyte dedifferentiation.
Animalslipid nanoparticle mRNA
RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026
Liver progenitor-like cells
upin animals1Very low certainty
1 study
Liver progenitor-like cells
upin animals1Very low certainty
OSKM induces liver progenitor-like cells.
Animalswithout injury
RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026
Latest
1RNA delivery linked to enhanced liver regeneration in mice
In mice, liver-targeted messenger RNA briefly induced reprogramming proteins and was associated with enhanced regeneration after acetaminophen-induced…In mice, liver-targeted messenger RNA briefly induced reprogramming proteins and was associated with enhanced regeneration after acetaminophen-induced injury.