DunedinPACE
Biomarker4 papers3 findings
- Humans4
Associations
3Major depressive disorder
upin humans1OR 1.46
1 study
Major depressive disorder
upin humans1OR 1.46
DunedinPACE is associated with Major depressive disorder in humans (OR = 1.46, 95% CI = 1.15 – 1.85).
Humans6 months after trauma6 monthsn = 660
Accelerated epigenetic aging predicts major depression and brain changes after trauma · medRxiv · 28 Sep 2026 · Preprint
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
DunedinPACE is associated with cognitive function in humans.
Humansretest-related gains within and across burstsn = 139
Epigenetic age acceleration tracks lower baseline cognition and greater retest gains · The journals of gerontology. Series A, Biological sciences and medical sciences · 26 Sep 2026
Adherence to danish dietary guidelines
downin humans1−3.1% lower pace of aging
1 study
Adherence to danish dietary guidelines
downin humans1−3.1% lower pace of aging
Adherence to danish dietary guidelines are associated with DunedinPACE in humans (3.1% lower pace of aging).
Humanscross-sectional individual analysesper 1 unit increase in index score
Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026
Latest
4Accelerated epigenetic aging predicts major depression and brain changes after trauma
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.
medRxiv · Navarro-Flores A et al.
Epigenetic age acceleration tracks lower baseline cognition and greater retest gains
In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change over time.
The journals of gerontology. Series A, Biological sciences and medical sciences · Zavala DV et al.
Blood methylation clocks capture two distinct biological domains of aging
Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors, and lifestyle exposures.
Genes · Austin KN et al.
Dietary benefits on epigenetic aging may largely reflect familial factors
A longitudinal study of Danish twins found individual-level dietary associations with biological age attenuated after controlling for shared genetics and early-life environment.
GeroScience · Nygaard M et al.