Pulmonary fibrosis
Disease4 papers4 findings
A human cohort links whole-blood MaGE-p16 to incident pulmonary fibrosis. In mouse models, Prkcq deletion, rapamycin, and Bapta-am each protect against lung fibrosis.
- Humans1
- Animals3
Interventions
3Bapta-am
downin mice1
1 study
Bapta-am
downin mice1
Bapta-am protects against pulmonary fibrosis in mice.
Animalslung
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026
Rapamycin
downin mice1
1 study
Rapamycin
downin mice1
Rapamycin protects against pulmonary fibrosis in mice.
Animalsbleomycin-induced pulmonary fibrosislung
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
Prkcq deletion
downin mice1
1 study
Prkcq deletion
downin mice1
Prkcq deletion decreases pulmonary fibrosis in mice.
Animalsbleomycin-inducedknockoutlung
Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence · Iranian journal of basic medical sciences · 1 Jan 2026
Associations
1MaGE-p16
upin humans1
1 study
MaGE-p16
upin humans1
MaGE-p16 is associated with pulmonary fibrosis in humans.
Humansincident diseasewhole bloodn = 18,859
DNA methylation proxies of senescence markers track human disease and mortality · medRxiv · 1 Oct 2026 · Preprint
Latest
6DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Biochimica et biophysica acta. General subjects · Xu J et al.
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Research Square · Liu M et al.