Mitochondrial replacement therapy

1. Mitochondrial replacement therapy decreases mitochondrial DNA in T. californicus.

   “and mitochondrial DNA content was lower than in hybrid controls.”

   Model organismscompared to hybrid controls

   Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus

   PloS one·24 Oct 2025

More on Mitochondrial DNA

1. Mitochondrial replacement therapy increases 8-hydroxy-2'-deoxyguanosine in T. californicus.

   “Oxidative DNA damage, measured by 8-hydroxy-2'-deoxyguanosine content, was higher in three-parent offspring”

   Model organismscompared to hybrid controls

   Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus

   PloS one·24 Oct 2025

More on 8-hydroxy-2'-deoxyguanosine

1. Mitochondrial replacement therapy has no effect on routine metabolic rate in T. californicus.

   “these "three-parent offspring" did not significantly differ in lifespan or routine metabolic rate.”

   Model organismscompared to hybrid controls

   Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus

   PloS one·24 Oct 2025

1. Mitochondrial replacement therapy has no effect on lifespan in T. californicus.

   “these "three-parent offspring" did not significantly differ in lifespan or routine metabolic rate.”

   Model organismscompared to hybrid controls

   Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus

   PloS one·24 Oct 2025