Mechanisms
Thu 1 Oct42 papers
ASXL1-mutant clonal hematopoiesis links to aortic valve disease
In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or…In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition. In an analysis of 449,109 participants in the UK Biobank, large clones and non-DNMT3A subtypes of clonal hematopoiesis of…
Spinal motor neuron excitability plateaus in very old age
In an observational study of 89 adults, estimates of motor neuron persistent inward currents fell by the seventh decade without further decline past…In an observational study of 89 adults, estimates of motor neuron persistent inward currents fell by the seventh decade without further decline past age 80. In a preprint study, researchers assessed spinal motor neuron excitability across 30 young adults, 30 older adults, and 29 very old…
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle…Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice. In human myogenic cells and mouse models, researchers investigated how variations in the androgen receptor control…
Stress and recovery dynamics reveal transcriptomic stability limits across aging mouse organs
Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young…Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young and aged mice. In a preprint study, researchers subjected young and aged mice to transient sleep deprivation to investigate dynamic stress…
Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes
A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging. In a preprint studying fruit flies and mice, researchers found that declining translational capacity is a causal driver of oocyte aging.
Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice
Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling. In a preprint study using mice, researchers examined how cathelicidin antimicrobial peptide, or CAMP, influences bone fracture repair across…
Glymphatic dysfunction is linked to brain aging in schizophrenia
In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and…In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging. In people with schizophrenia, impaired glymphatic clearance is tied to inflammation and accelerated aging, according to a…
Plasma asparagine links to lower cardioembolic stroke risk
In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio…In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio yielded an odds ratio of 1.148.
Proteostasis and ageing dissidence
Weight gain, adipose tissue remodeling and cardiometabolic disease in people with HIV
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming…Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory…Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions. In experiments using cultured fibroblasts and an in vivo animal model, researchers examined how intracellular calcium changes…
PFOS exposure is linked to higher glaucoma risk in humans
An analysis of NHANES participants from 2005 to 2008 and Mendelian randomization linked PFOS exposure to higher glaucoma risk.An analysis of NHANES participants from 2005 to 2008 and Mendelian randomization linked PFOS exposure to higher glaucoma risk. In an analysis of human survey data from NHANES (2005–2008), researchers examined single and mixed perfluoroalkyl substance (PFAS) exposures in relation to ocular…
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and…Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance. In mice and cultured mouse myoblasts, researchers examined the role of PNPLA7 in phosphatidylcholine turnover and skeletal muscle…
Condition-specific role of ankle proprioception in postural control in older adults: a stabilogram diffusion analysis approach
Air pollutants link to disease through distinct proteomic paths
In 48,645 UK Biobank participants, plasma proteomic profiles linked ambient air pollutants to mortality and chronic diseases through shared immune and…In 48,645 UK Biobank participants, plasma proteomic profiles linked ambient air pollutants to mortality and chronic diseases through shared immune and divergent molecular pathways.
Genetics of Obesity: Discovery, Biology, Prediction, and Therapeutic Implications
Fetal gene Lin28b improves ex vivo expansion of aged mouse blood stem cells
Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse…Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse hematopoietic stem cells. Researchers studied hematopoietic stem cells from mouse fetal liver, young bone marrow, and aged bone marrow to examine…
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan. In Caenorhabditis elegans, depletion of the mitochondrial prohibitin complex shortens life in wild-type animals but extends it in long-lived daf-2…
The Roles of Lipoprotein(a) in Atherosclerosis - Minding the Knowledge Gaps
Clinical Translation of Mesenchymal Stem Cells to Medicinal Signaling Cells: Origins, Clinical Applications, and the Future of Regenerative Medicine-2026 Arnold I. Caplan Award for Distinguished Research in Orthobiologics
Cortical surface areas link to fall-related fracture odds
Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05).Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05). In a bidirectional two-sample Mendelian randomization study of more than 51,000 Europeans, researchers tested whether cortical thickness or…
Aging Language: Understanding How Human Cognition Changes As We Grow Old
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Distracted driving slows emergency braking in older adults
In a driving simulator, dual-demand trials slowed older drivers' braking to 776 ms versus 605 ms in younger adults, with error rates reaching 11.67%…In a driving simulator, dual-demand trials slowed older drivers' braking to 776 ms versus 605 ms in younger adults, with error rates reaching 11.67% compared to 3.04%. In a driving simulator study of 44 licensed drivers, researchers compared 23 younger adults aged 19 to 25 with 21 older…
