Interventions

Wed 30 Sep68 papers

bioRxivAnimalsPreprint

Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice

Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease. In mice, researchers investigated whether factors secreted by astrocytes could rescue adult hippocampal neurogenesis and cognitive performance.

A mouse and a secreting astrocyte above two cross-sections of the hippocampus showing sparser and denser populations of neurons.
Alzheimer's disease
Research SquareAnimalsPreprint

Exercise prevents doxorubicin-induced cardiac senescence in mice

In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting…In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting senescence in cultured human cells.

A scarred heart and irregular cells beside a resting mouse contrast with a healthy heart and uniform cells beside a mouse running on an exercise wheel.
Exercise
FASEB JournalAnimals

4-Octyl itaconate restores parotid gland function in aging mice

The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways. In 13-month-old male mice, daily treatment with 4-octyl itaconate for four weeks restored salivary secretion in aging parotid glands.

Graphical abstract
Gut and microbiome
EMBO ReportsModel organisms

Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes

Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits. In the nematode Caenorhabditis elegans, researchers found that alpha-synuclein progressively alters lipid metabolism during aging.

Figure 1
Oxidative phosphorylation
Nature AgingHuman trial

Exercise-primed vesicles enhance cartilage health in aged mice

Intra-articular administration of exercise-primed extracellular vesicles enhanced cartilage health in aged mice.Intra-articular administration of exercise-primed extracellular vesicles enhanced cartilage health in aged mice. In older adults, a three-month aerobic exercise intervention increased microRNA-29 levels in extracellular vesicles relative to baseline.

Figure 1
Aerobic exercise
Nature CommunicationsHuman trial

Multidisciplinary care reduces frailty in older cardiac patients

In a randomized trial, the year-long RENAP regimen yielded an adjusted mean difference of -0.79 in frailty and 2.02 in physical performance against…In a randomized trial, the year-long RENAP regimen yielded an adjusted mean difference of -0.79 in frailty and 2.02 in physical performance against usual care. In a multicentre trial of 333 frail inpatients aged 70 and older with cardiovascular diseases in Beijing, researchers tested the…

Flow of participants through the study.
Cardiovascular disease
Journal of the National Cancer InstituteHuman trial

Exercise missed primary cognitive goals in cancer survivors

In 253 breast cancer survivors, a 12-month exercise program failed to beat wellness calls on primary cognitive tests, despite selective gains in…In 253 breast cancer survivors, a 12-month exercise program failed to beat wellness calls on primary cognitive tests, despite selective gains in attention and memory. In a randomized controlled trial of 253 breast cancer survivors, researchers tested whether a remotely delivered 12-month…

Exercise
Pharmacological ResearchCells

Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells

Vesicles from melatonin-treated stem cells targeted SRSF1 and SP1 to lower progerin and cellular prion protein in cell models.Vesicles from melatonin-treated stem cells targeted SRSF1 and SP1 to lower progerin and cellular prion protein in cell models. In experiments using human cellular models and serum from an index patient with Hutchinson-Gilford progeria syndrome, researchers tested small extracellular…

Graphical abstract
Aging CellModel organisms

Direct AMPK activation extends lifespan across yeast, worms, and flies

Treatment with the direct activator 991 also induced a pro-longevity proteomic profile in mice.Treatment with the direct activator 991 also induced a pro-longevity proteomic profile in mice. In yeast, roundworms, and fruit flies, direct pharmacological activation of AMPK extends lifespan.

Graphical abstract
Biomaterials AdvancesAnimals

Engineered exosome-mimetic nanoparticles improve liver function in aged mice

The synthetic particles deliver microRNAs and proteins to reduce senescence, lower fibrosis, and shift macrophages toward a pro-resolving state.The synthetic particles deliver microRNAs and proteins to reduce senescence, lower fibrosis, and shift macrophages toward a pro-resolving state. In aged mice, systemic treatment with engineered exosome-mimetic lipid nanoparticles revitalized baseline liver function.

Graphical abstract
Blood and immune system
Clinical Journal of the American Society of NephrologyHumans

SGLT2 inhibitors match GLP-1 drugs for overall kidney outcomes

In older veterans, primary kidney and survival risks matched with a hazard ratio of 1.00, though SGLT2 inhibitors showed lower sustained kidney…In older veterans, primary kidney and survival risks matched with a hazard ratio of 1.00, though SGLT2 inhibitors showed lower sustained kidney decline and end-stage disease. The observational study evaluated 28,365 GLP-1RA and 78,354 SGLT2i initiators among US Veterans aged 65 years and…

GLP-1 receptor agonists
Aging CellAnimals

Dietary CoQ10 ameliorates megakaryocyte dysfunction in aged mice

Male mice treated with CoQ10 for 12 weeks showed enhanced megakaryocyte maturation and polyploidization, accompanied by reduced platelet aggregation…Male mice treated with CoQ10 for 12 weeks showed enhanced megakaryocyte maturation and polyploidization, accompanied by reduced platelet aggregation and activation. Male C57BL/6J mice aged 1 to 23 months received dietary coenzyme Q10 for 12 weeks to evaluate megakaryocyte homeostasis and…

Graphical abstract
Blood and immune system
Diabetes & Vascular Disease ResearchHumans

SGLT2 inhibitors link to lower dementia risk than GLP-1 drugs

Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2…Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors. In a retrospective study of adults aged 60 and older with type 2 diabetes, researchers compared outcomes between sodium-glucose…

SGLT2 inhibitors