Extracellular matrix
Cell component20 papersMeSH D005109GO 0031012
- Humans6
- Animals7
- Model organisms1
- Cells2
Latest
20Human aortic elastin degrades with age in males but not females
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not…In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.
Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
Aged perivascular fat worsens aortic stiffness in mice
Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat…Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat collagen levels.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment…Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Synergistic Effects of Solar Exposure and Skin Sensitivity on Skin Aging: A Clinical Study Using Multimodal Noninvasive Measurements
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming…Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
PFOS exposure is linked to higher glaucoma risk in humans
An analysis of NHANES participants from 2005 to 2008 and Mendelian randomization linked PFOS exposure to higher glaucoma risk.An analysis of NHANES participants from 2005 to 2008 and Mendelian randomization linked PFOS exposure to higher glaucoma risk.
Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice
The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.
Faulty debris clearance promotes ovarian fibroinflammation in mice
Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells…Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized fibroinflammation.
Killifish exhibit distinct structural changes and fibrosis during cardiac aging
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical…Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
Lactate receptor activation reduces arterial senescence in mice
In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved…In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved endothelial integrity.
Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes
The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.