Heterocephalus glaber

1. Hypoxia protects against mitochondrion in naked mole-rats.

   “Moreover, long-lived species preserved mitochondrial health under hypoxia, likely contributing to their extended lifespan.”

   Animalsunder hypoxia in long-lived species0% O2heart

   Interconnections of Hypoxia and Aging in Long-Lived Species · GSA 2025 abstract · 31 Dec 2025

2. Hypoxia decreases oxidative stress and ROS signalling in naked mole-rats.

   “Notably, enhanced AMPK signaling, elevated autophagy-related protein levels, and reduced oxidative stress in these species suggest a strong link”

   Animalsunder hypoxia in long-lived species0% O2heart

   Interconnections of Hypoxia and Aging in Long-Lived Species · GSA 2025 abstract · 31 Dec 2025

3. Hypoxia activates AMPK signalling in naked mole-rats.

   “Notably, enhanced AMPK signaling, elevated autophagy-related protein levels, and reduced oxidative stress in these species suggest a strong link between longevity and hypoxia resilience.”

   Animalsunder hypoxia in long-lived species0% O2heart

   Interconnections of Hypoxia and Aging in Long-Lived Species · GSA 2025 abstract · 31 Dec 2025

4. Hypoxia improves survival in naked mole-rats.

   “results demonstrated that long-lived species survived hypoxia significantly better than mice.”

   Animalscompared to mice under severe hypoxia (0% O2)0% O2

   Interconnections of Hypoxia and Aging in Long-Lived Species · GSA 2025 abstract · 31 Dec 2025

Hypoxia →

1. Ultra-high molecular weight hyaluronan is associated with cancer in naked mole-rats.

   “whose exceptional longevity and cancer resistance have been linked to abundant UHMW-HA”

   Review

   Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules · Preprints.org · 4 Sep 2026 · Preprint

2. Ultra-high molecular weight hyaluronan is associated with longevity in naked mole-rats.

   “whose exceptional longevity and cancer resistance have been linked to abundant UHMW-HA”

   Review

   Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules · Preprints.org · 4 Sep 2026 · Preprint

Ultra-high molecular weight hyaluronan →