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TRPM2

There are 7 papers on TRPM2 in aging research: 1 observational study in people, 6 in animals. The newest story, Nov 3, 2026: “Calcium channel links radiation to salivary gland problems in mice”.

Gene

7 papers study it14 findings

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1 new paper in 30 daysSee all 7 papers on TRPM2

At a glance

The findings reach people, from one lab or study. 5 independent labs in 4 countries.

“TRPM2) channel is preferentially expressed in vulnerable DA neuronal subgroups, which correlates positively with aging in Parkinson's Disease (PD) patients.”
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasisProgress in neurobiology2023doi:10.1016/j.pneurobio.2023.102530

None of its findings points the other way.

Cells, worms or flies, mice and humans: a single group.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 5 independent labs in 4 countries
  • Funders: Fundamental Research Funds for the Central Universities and others
  • Humans1
  • Animals6

Interventions

2

Duloxetine

downin mouse cells1

1 study

  1. Duloxetine inhibits TRPM2 in mouse cells.

    “duloxetine-mediated inhibition of TRPM2 (transient receptor potential cation channel subfamily M member 2) ion channels.”

    Cells

    Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy

    Autophagy

More on Duloxetine

Selenium

downin rat cells1

1 study

  1. Selenium inhibits TRPM2 in scopolamine-treated rat hippocampal and DRG neurons.

    “Se was fully effective in reversing SCOP-induced TRPM2 and TRPV1 current densities”

    Cellsin scopolamine-treated rat hippocampal and DRG neurons

    The Protective Role of Selenium on Scopolamine-Induced Memory Impairment, Oxidative Stress, and Apoptosis in Aged Rats: The Involvement of TRPM2 and TRPV1 Channels

    Molecular neurobiology

More on Selenium

Effects

11

DNA repair

downin mice1

1 study

  1. TRPM2 inhibits DNA repair in mice (shown by loss of TRPM2).

    “loss of TRPM2 decreases cellular senescence, restores mitochondrial Ca2+ handling and bioenergetics, along with DNA repair and protein synthesis.”

    Animalsshown by loss of TRPM2

    Calcium channel links radiation to salivary gland problems in mice

    iScience

More on DNA repair

Mitochondrial Ca2+ handling

downin mice1

1 study

  1. TRPM2 impairs mitochondrial Ca2+ handling in mice (shown by loss of TRPM2).

    “loss of TRPM2 decreases cellular senescence, restores mitochondrial Ca2+ handling and bioenergetics”

    Animalsshown by loss of TRPM2

    Calcium channel links radiation to salivary gland problems in mice

    iScience

Cellular senescence

upin mice1

1 study

  1. TRPM2 increases cellular senescence in mice (shown by loss of TRPM2).

    “Mechanistically, our data show that loss of TRPM2 decreases cellular senescence”

    Animalsshown by loss of TRPM2

    Calcium channel links radiation to salivary gland problems in mice

    iScience

More on Cellular senescence

Salivary gland dysfunction

upin mice1

1 study

  1. TRPM2 increases salivary gland dysfunction in mice after irradiation; shown by Trpm2 knockout.

    “Trpm2−/− mice were resistant to irradiation-induced salivary gland dysfunction at the acute/early stage of post-irradiation.”

    Animalsafter irradiation; shown by Trpm2 knockoutsalivary glandacute/early stage of post-irradiation

    Calcium channel links radiation to salivary gland problems in mice

    iScience

More on Salivary gland dysfunction

Substantia nigra pars compacta dopaminergic neuron death

upin mice1

1 study

  1. TRPM2 increases substantia nigra pars compacta dopaminergic neuron death in mice (stress-induced neuronal death; shown by knockout).

    “In mice, TRPM2 knockout reduced vulnerable substantia nigra pars compacta (SNc) DA neuronal death induced by stress.”

    Animalsstress-induced neuronal death; shown by knockoutsubstantia nigra pars compacta

    TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis

    Progress in neurobiology

mitochondrial permeability transition

upin worms1

1 study

  1. TRPM2 induces mitochondrial permeability transition in worms (FZO-1/CED-9-dependent).

    “TRPM2 activation mediates FZO-1/CED-9-dependent mitochondrial hyperfusion and mitochondrial permeability transition (MPT), leading to ADE death.”

    Model organismsFZO-1/CED-9-dependentADE neuron

    TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis

    Progress in neurobiology

Mitochondrial hyperfusion

upin worms1

1 study

  1. TRPM2 induces mitochondrial hyperfusion in worms (FZO-1/CED-9-dependent).

    “TRPM2 activation mediates FZO-1/CED-9-dependent mitochondrial hyperfusion and mitochondrial permeability transition (MPT), leading to ADE death.”

    Model organismsFZO-1/CED-9-dependentADE neuron

    TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis

    Progress in neurobiology

ADE neuron death

upin worms1

1 study

  1. TRPM2 increases ADE neuron death in worms (human TRPM2 overexpression in dopaminergic neurons).

    “Overexpression of human TRPM2 in the DA neurons of C. elegans resulted in selective death of ADE but not CEP neurons in aged worms.”

    Model organismshuman TRPM2 overexpression in dopaminergic neuronsADE neuron

    TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis

    Progress in neurobiology

Inflammation

upin mice1

1 study

  1. TRPM2 increases inflammation in mice (TRPM2 knockout mice compared with wild-type mice during aging).

    “an increase in the number of Iba1-positive cells and amounts of pro-inflammatory cytokines in the brain; these characteristics were not seen in TRPM2-KO mice”

    AnimalsTRPM2 knockout mice compared with wild-type mice during agingbrain

    Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice

    Neuroscience

More on Inflammation

White matter injury

upin mice1

1 study

  1. TRPM2 increases white matter injury in mice (TRPM2 knockout mice compared with wild-type mice during aging).

    “these characteristics were not seen in TRPM2-KO mice”

    AnimalsTRPM2 knockout mice compared with wild-type mice during agingwhite matter

    Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice

    Neuroscience

All 11

Associations

1

Age

upin humans1

1 study

  1. TRPM2 is associated with age in humans (Parkinson's disease).

    “TRPM2) channel is preferentially expressed in vulnerable DA neuronal subgroups, which correlates positively with aging in Parkinson's Disease (PD) patients.”

    HumansParkinson's diseasedopaminergic neuron

    TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis

    Progress in neurobiology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 12 papers in 12 months
iScience

Calcium channel links radiation to salivary gland problems in mice

Mice lacking the channel resisted early salivary gland dysfunction after irradiation; the authors linked its effects to cells entering a nondividing state.Mice lacking the channel resisted early salivary gland dysfunction after irradiation; the authors linked its effects to cells entering a nondividing state.

Mouse studyMechanisms
Paper

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