Farnesylation amino acid targeted editing

Intervention1 paper3 findings

Outcomes

Progeria

downin human cells1

1 study

Farnesylation amino acid targeted editing protects against progeria in human cells.
CellsmRNA conjugated with lipid nanoparticlesneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

DNA repair

upin human cells1

1 study

Farnesylation amino acid targeted editing activates DNA repair in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

TP53BP1

upin human cells1

1 study

Farnesylation amino acid targeted editing improves TP53BP1 in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

CellsPeer-reviewed1 Oct

Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.

Nature communications · Kim DW et al.