POLK
Gene1 paper3 findingsHGNC 9183NCBI Gene 51426Taxon 9606
- Cells1
Effects
3Cytoplasmic dsDNA
downin human cells1
1 study
Cytoplasmic dsDNA
downin human cells1
POLK decreases cytoplasmic dsDNA in human cells.
CellsPOLK augmentation
DNA polymerase kappa supports genome repair in cultured neurons · bioRxiv · 4 Oct 2026 · Preprint
Phospho-tau
downin human cells1
1 study
Phospho-tau
downin human cells1
POLK decreases phospho-tau in human cells.
Cellsin APOE e4/e4 neurons
DNA polymerase kappa supports genome repair in cultured neurons · bioRxiv · 4 Oct 2026 · Preprint
DNA repair
upin human cells1
1 study
DNA repair
upin human cells1
POLK increases DNA repair in human cells.
Cellsshown by depletion reducing EdU incorporation
DNA polymerase kappa supports genome repair in cultured neurons · bioRxiv · 4 Oct 2026 · Preprint
Latest
1DNA polymerase kappa supports genome repair in cultured neurons
In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered…In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers.