Universitair Medisch Centrum Groningen

• Jamil Nehme

  Lead investigator

• Deniz Başkent

  Lead investigator

• Stijn Mouton

  Lead investigator

• Eugene Berezikov

  Lead investigator

• Federica Sarno

  Lead investigator

• Cor Calkhoven

  Lead investigator

• Marco Demaria

  Lead investigator

• Gerald Haan

  Lead investigator

• prof. dr. M Demaria

  Lead investigator

• dr. H.J. Luijendijk MD PhD

  Lead investigator

• prof. dr. E. Berezikov

  Lead investigator

• Monique Wijst

  Lead investigator

• Wisman

  Lead investigator

• dr. A. Kooy MD PhD

  Lead investigator

• prof. dr. R. Vliegenthart MD PhD

  Lead investigator

• Dr. J.K. Kruit

  Lead investigator

• Prof. dr. R. Dekker

  Lead investigator

• Jourik Gietema

  Lead investigator

• B - Ćurčić-Blake

  Lead investigator

• Prof. dr. S.E.J.A. de Rooij

  Lead investigator

Sources: openalex.org

• Screening and the Future of Enhanced MRI for Early Breast Cancer Detection

  Collaborator, Not yet recruiting, 2,628 people, Oct 16, 2026

• NCT07819227

  Phase 2, Completed, 41 people, Sep 14, 2026

• NCT07632079

  Collaborator, Phase 2, Recruiting, 60 people, Jun 8, 2026

• NCT07304817

  Phase 2, Recruiting, 100 people, Dec 26, 2025

• NCT07239570

  Collaborator, Phase 4, Recruiting, 125 people, Nov 20, 2025

• NCT07234422

  Collaborator, Phase 3, Recruiting, 1,100 people, Nov 18, 2025

• NCT07206290

  Phase 2, Not yet recruiting, 120 people, Oct 3, 2025

• NCT07181135

  Phase 3, Enrolling by invitation, 180 people, Sep 18, 2025

• NCT07108855

  Phase 1/2, Recruiting, 10 people, Aug 7, 2025

• NCT06923475

  Collaborator, Phase 2/3, Recruiting, 150 people, Apr 11, 2025

• Supplemental Screening for Women With Extremely Dense Breast Tissue: the DENSE-2 Trial

  Collaborator, Recruiting, 36,000 people, Oct 10, 2024

• NCT06616142

  Phase 1/2, Recruiting, 12 people, Sep 27, 2024

• NCT06374043

  Phase 4, Completed, 20 people, Apr 18, 2024

• NCT06101745

  Collaborator, Phase 2/3, Recruiting, 336 people, Oct 26, 2023

• NCT06094920

  Phase 4, Completed, 12 people, Oct 23, 2023

• dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation

  Phase 2, Not yet recruiting, 36 people, Oct 10, 2023

• NCT05949424

  Phase 4, Status unknown, 30 people, Jul 18, 2023

• NCT05639127

  Early phase 1, Status unknown, 12 people, Dec 6, 2022

• NCT05570305

  Phase 2, Completed, 42 people, Oct 6, 2022

• NCT05565976

  Collaborator, Phase 2/3, Status unknown, 270 people, Oct 4, 2022

Sources: clinicaltrials.gov

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS pakket 25-1, LIF6: A Genetic Key to Cancer Resistance and Healthy Aging?, OCENW.XS25.1.171, 2025, May 1, 2025

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open technologieprogramma OTP 2024 2024-4, ATHENA: Automating hearing assessments for all, 21764, 2025, Apr 1, 2025

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS pakket 24-4, Improving healthy ageing by manipulating snoRNA expression, OCENW.XS24.4.054, 2025, Feb 1, 2025

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS pakket 24-3, Developing transient reprogramming approaches in an invertebrate model organism toward research on anti-ageing and ageing-related disease treatment strategies, OCENW.XS24.3.235, 2025, Jan 1, 2025

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS pakket 24-3, Rejuvenating pre-Fibrotic Kidneys for Transplantation Through Epigenetic Editing, OCENW.XS24.3.122, 2024, Nov 15, 2024

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  NWO-ENW Wetenschappelijke Bijeenkomsten en Ontmoetingen Algemeen ENW WBO 2023 WBO 2023-1, The Groningen-Jena Aging Meeting (G-JAM) 2023, 20776, 2023, Sep 28, 2023

• KWF Kankerbestrijding

  Basaal/fundamenteel onderzoek, Zich richten op cellulaire senescence om door anthracyclines geïnduceerde toxiciteit te verlichten, 14547, 2023, Feb 1, 2023

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW - M 2020/2021 M20-1, Identification and functional characterization of hematopoietic stem cell aging genes, OCENW.M20.002, 2022, Mar 1, 2022

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS pakket 21-1, Slowing down ageing: from immortal planarians to short-lived yeast, OCENW.XS21.1.025, 2022–2023, Jan 1, 2022

• ZonMw

  ["Vidi"], Characterizing and targeting detrimental senescence to promote healthy aging, zonmw-09150172010029-36787, 2022–2027, Jan 1, 2022

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW XS Pilot 2019-2020 deadline 4, Learning from an immortal animal how to improve protein homeostasis and slow down ageing, OCENW.XS4.076, 2021–2022, Feb 1, 2021

• ZonMw

  ["Huisartsgeneeskunde en Ouderengeneeskunde"], Discontinuation of preventive cardiovascular medication in older community-dwelling patients: current practice and patient preferences, zonmw-839150003-25674, 2020–2025, Sep 1, 2020

• ZonMw

  ["ZonMw Open Competitie"], Molecular engineering of healthspan extension leveraging genetics of aging-resilient animals, zonmw-09120011910011-36697, 2020–2025, Feb 1, 2020

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  NWO-Talentprogramma Veni ENW 2019, Strength through diversity? The impact of cell-to-cell variation in gene expression levels during immune aging., VI.Veni.192.029, 2020–2023, Feb 1, 2020

• Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Open Competitie ENW - M Doorlopend OC ENW KLEIN Pakket 02, Stem cell differentiation programs in the regenerative flatworm Macrostomum lignano, OCENW.KLEIN.054, 2020–2023, Jan 1, 2020

• ZonMw

  ["Preventie 5: Deelprogramma 5 - Vroege opsporing"], CIN2+-specific methylation markers in the triage of hrHPV-positive self-samples will improve efficacy of population-based cervical cancer screening, zonmw-531002021-25337, 2019–2024, Aug 15, 2019

• ZonMw

  Geneesmiddelen, Pregnancy Outcomes: Effects of Metformin (POEM) study: a long term randomized controlled trial, zonmw-848017010-25276, 2019–2023, May 1, 2019

• ZonMw

  ["IMDI"], B3CARE, zonmw-104006003-26794, 2019–2023, Jan 3, 2019

• ZonMw

  ["Partnership Diabetes"], Selective clearance of aged cells; a new cure for type 2 diabetes?, zonmw-459001005-24742, 2018–2021, Oct 15, 2018

• ZonMw

  ["Onderzoeksprogramma Sport en Bewegen 2017-2020"], PIE=M; Physicians Implement Exercise is Medicine. The implementation of individualized active lifestyle prescription in routine clinical care; E=M., zonmw-546001002-24178, 2018–2021, Sep 15, 2018

Sources: openalex.org

• Exploring Socioeconomic Disparities: The Association between the Mediterranean Lifestyle and Mortality across Education and Income Levels in the Prospective Lifelines Cohort

  Oct 9, 2026

• Serum T50 is not independently associated with coronary artery calcification in early chronic kidney disease

  Oct 5, 2026

• Depressive symptom profiles and risk of cardiometabolic disease incidence

  Oct 2, 2026

• Six-year trajectories of cognitive, physical and social functioning in adults with late-life depression

  Sep 9, 2026

• Normal Tissue Complication Probability Estimation for Metabolic Syndrome in Survivors of the Dutch National Wilms Tumor Cohort: A DCCSS-LATER Study

  Sep 1, 2026

• The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets

  Aug 20, 2026

• Socioeconomic inequalities in the association between diet quality and incident cardiovascular diseases: A prospective study in the Netherlands

  Jul 6, 2026

• The Association Between Relocations and Health Outcomes in Nursing Home Residents: A Retrospective Cohort Study

  Jul 3, 2026

• Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-β modulation

  Jun 30, 2026

• Associations between dietary food categories, epigenetic age acceleration and low-grade inflammation in the Lifelines-DEEP cohort

  May 29, 2026

• Mapping the canine gut microbiome: insights from the Dog Aging Project

  May 19, 2026

• Biological aging as a mediator of the association between air pollution and all-cause mortality and hospitalization: Evidence from the UK Biobank and Lifelines cohorts

  May 15, 2026

• Biological age acceleration, longitudinal change and mortality risk in the Dutch Lifelines cohort

  Apr 14, 2026

• Adverse childhood experiences and sarcopenia: a prospective study embedded in the Canadian Longitudinal Study on Aging

  GrAGIKO 19-03, Mar 16, 2026

• Brain irradiation drives remote liver changes via senescence-independent mechanisms

  Jan 9, 2026

• Mortality among Older Adults Across Multimorbidity Categories and Lifestyle Patterns

  Jan 8, 2026

• Enhanced C/EBPα Function Extends Healthspan and Lifespan in the African Turquoise Killifish

  Sep 19, 2025

• Difference between Okinawan and Dutch older adults in prefrontal brain activation

  Jul 31, 2025

• Patterns of time spent in sedentary behavior, physical activity, and sleep are associated with cognitive decline among CLSA participants: A latent class analysis

  Jun 27, 2025

• Microbiome variations in osteoarthritis reflect aging and metabolic factors, not the disease

  Jun 25, 2025

Sources: api.crossref.org, openalex.org

• Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation

  Grants or research support, Mar 1, 2024

Sources: pubmed.ncbi.nlm.nih.gov

• AI chest scan measurements may help predict heart failure

  American journal of preventive cardiology, Oct 18, 2026

• Effects of Exercise Training on the Metabolic Cost of Walking in Health and Disease: A Systematic Review and Meta-analysis

  Sports medicine (Auckland, N.Z.), Oct 14, 2026

• Validation of the Klinrisk CKD Progression Model in the Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) Population

  Kidney360, Oct 14, 2026

• Supplemental Breast Cancer Screening with Contrast-enhanced Mammography or Abbreviated MRI for Extremely Dense Breasts: The DENSE-2 Trial

  Radiology, Oct 13, 2026

• Duodenal involvement in MUTYH-associated polyposis: findings from an international study and implications for endoscopic surveillance

  The American journal of gastroenterology, Oct 13, 2026

• Serum T50 is not independently associated with coronary artery calcification in early chronic kidney disease

  Clinical kidney journal, Oct 13, 2026

• Mediterranean lifestyle linked to lower risk of death

  The American journal of clinical nutrition, Oct 10, 2026

• Association between stress-related exposures and risk of pre-diabetes and type 2 diabetes: results from the population-based Lifelines cohort study

  BMJ open diabetes research & care, Oct 9, 2026

• Poorer very high-frequency hearing linked to weaker brain responses

  NeuroImage, Oct 6, 2026

• Comparing three approaches to delirium identification in older patients presenting to the emergency department

  European geriatric medicine, Oct 5, 2026

• AI detects coronary calcium in adults with zero scores

  American journal of preventive cardiology, Oct 4, 2026

• Cellular senescence: six decades of discovery and reinvention

  The EMBO journal, Oct 3, 2026

• Depressive symptom profiles and risk of cardiometabolic disease incidence

  Journal of affective disorders, Oct 3, 2026

• TET deficiency drives selection of aneuploid cells in mice

  bioRxiv, Oct 2, 2026

• Importance of faecal sample collection in prospective cohort studies to evaluate the effect of the gut microbiome on cancer development

  The Lancet. Microbe, Oct 2, 2026

• Survodutide reduces weight in adults with diabetes and obesity

  The New England journal of medicine, Oct 2, 2026

• Microglia-derived extracellular vesicle content as a biomarker for early detection of Alzheimer's disease

  Translational neurodegeneration, Oct 1, 2026

• Vitamin D status and colorectal neoplasm risk in Lynch syndrome

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Oct 1, 2026

• Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes

  EMBO reports, Sep 30, 2026

• Effects of Polygenic Risk Scores and Physical Activity on Blood Pressure Trajectories in Childhood, Adolescence, and Young Adulthood

  Circulation. Genomic and precision medicine, Sep 24, 2026