Telomerase activity
Biomarker3 papers1 findingMeSH D019098
- Human trial2
- Model organisms1
Interventions
1Metformin
upin humans1+39% increaseModerate certainty
1 study
Metformin
upin humans1+39% increaseModerate certainty
Metformin increases telomerase activity in humans (39.3% increase).
Human trialprediabetespbmc500 mg twice daily24 weeksn = 127
Metformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial · Mechanisms of ageing and development · 3 Sep 2026
Funding
National Institute of General Medical SciencesUS$852.5kNational Institute on AgingUS$686.7kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$626.7k5 grants since 2015
Telomerase in Alzheimer’s Disease Pathogenesis and Treatment
National Institute on AgingUniversity of Tx Md Anderson Can CtrUS$686.7k2026–2027
Telomerase RNP Prisonbreaks from Phase-Separated Nuclear Body
National Institute of General Medical SciencesResearch Inst of Fox Chase Can CtrUS$470k2023–2028
Metabolic regulation and manipulation of telomerase in hematopoiesis
National Institute of Diabetes and Digestive and Kidney DiseasesBoston Children's HospitalUS$626.7k2015–2031
NIH Office of the DirectorUniversity of Michigan at Ann ArborUS$191.6k2025–2027
Regulation of human telomerase
National Institute of General Medical SciencesWashington State UniversityUS$382.5k2023–2028