Dehydroepiandrosterone

1. Dehydroepiandrosterone decreases lipofuscin in rats.

   “Ultrastructural examination of the frontal cortex revealed reductions in lipofuscin and lysosomal degradation following DHEA administration.”

   Animalsin aging ratsfrontal cortex30 mg/kg body weightmales

   Therapeutic Potential of Dehydroepiandrosterone in Reversing Age‐Related Neurodegenerative and Cognitive Declines in Rats · AAIC 2025 abstract · 23 Dec 2025

Lipofuscin →

1. Dehydroepiandrosterone increases SYNAPTOPHYSIN in rats.

   “elevated synaptic proteins, such as synaptophysin and synapsin I.”

   Animalsin aging ratssynaptosomes30 mg/kg body weightmales

   Therapeutic Potential of Dehydroepiandrosterone in Reversing Age‐Related Neurodegenerative and Cognitive Declines in Rats · AAIC 2025 abstract · 23 Dec 2025

SYNAPTOPHYSIN →

1. Dehydroepiandrosterone improves cognitive function in rats.

   “DHEA treatment significantly improved cognitive performance and memory in aging rats”

   Animalsin aging rats30 mg/kg body weightmales

   Therapeutic Potential of Dehydroepiandrosterone in Reversing Age‐Related Neurodegenerative and Cognitive Declines in Rats · AAIC 2025 abstract · 23 Dec 2025