Carotid intima-media thickness

1. Carotid intima-media thickness mediates cardiovascular disease in humans (3.64 % (95 % CI: 2.76 %-4.80 %)).

   Humansaccounting for 3.64% of effect of CVH on CVD

   Carotid thickness partly mediates cardiovascular health benefits · American journal of preventive cardiology · 6 Mar 2026

Cardiovascular disease →

1. Notch1 extracellular domain is associated with carotid intima-media thickness in humans (r = 0.475, p = 0.005).

   Human trialfollowing exercisen = 29

   The Influence of Age on Notch1 and VEGF-A Responses During Exercise · Journal of aging research · 29 Sep 2026

Notch1 extracellular domain →

1. Type 2 diabetes is associated with carotid intima-media thickness in humans (0.619 vs. 0.592 mm).

   “Mean cIMT was numerically higher in T2DM (0.619 vs. 0.592 mm; p = 0.284).”

   Humanscross-sectional comparison

   Type 2 Diabetes, Visceral Adiposity, and Carotid Intima-Media Thickness in Hospitalized Adults: A Retrospective Cross-Sectional Analysis · Medicina (Kaunas, Lithuania) · 3 Sep 2026

Type 2 diabetes →

1. Visceral fat area is associated with carotid intima-media thickness in humans (ρ = 0.237).

   “Visceral fat area correlated with cIMT before adjustment ( ρ = 0.237; p = 0.005), but not after adjustment.”

   Humansunadjusted Spearman correlation

   Type 2 Diabetes, Visceral Adiposity, and Carotid Intima-Media Thickness in Hospitalized Adults: A Retrospective Cross-Sectional Analysis · Medicina (Kaunas, Lithuania) · 3 Sep 2026

Visceral fat area →

1. Age is associated with carotid intima-media thickness in humans (β = 0.057 mm/decade).

   “Age ( β = 0.057 mm/decade; p β = 0.046 mm; p = 0.042) retained adjusted associations with cIMT.”

   Humansadjusted multivariable linear regression

   Type 2 Diabetes, Visceral Adiposity, and Carotid Intima-Media Thickness in Hospitalized Adults: A Retrospective Cross-Sectional Analysis · Medicina (Kaunas, Lithuania) · 3 Sep 2026

1. Carotid intima-media thickness raises the risk of cardiovascular disease in humans (HR: 1.06, 95 % CI: 1.06-1.07).

   Humansper 0.1 mm higher

   Carotid thickness partly mediates cardiovascular health benefits · American journal of preventive cardiology · 6 Mar 2026

Cardiovascular disease →

1. Cardiovascular health metrics lower the risk of carotid intima-media thickness in humans (-0.014 mm; OR 0.88, 95% CI 0.86-0.90).

   Humanshighest LS7 quartile compared to lowest quartile

   Carotid thickness partly mediates cardiovascular health benefits · American journal of preventive cardiology · 6 Mar 2026