Ilp6
- 1 lab in 1 country
- Funder: Agencia Nacional de Promoción Científica y Tecnológica
- Model organisms1
Effects
1Insulin/IGF-1 signalling
downin flies1
1 study
Insulin/IGF-1 signalling
downin flies1
Ilp6 decreases insulin/IGF-1 signalling in flies.
“Dilp6 acts nonautonomously to suppress Dilp2 secretion from IPCs, reducing systemic IIS and promoting longevity.”
Model organismsDcr-1 reductionfat body
Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8-Aop-Dilp6 axis
Proceedings of the National Academy of Sciences of the United States of America24 Mar 2026