IGF1
Gene2 papers2 findingsHGNC 5464MGI 96432NCBI Gene 3479Taxon 9606
- Animals1
Effects
1Mitochondrial dysfunction
downin mouse cells1
1 study
Mitochondrial dysfunction
downin mouse cells1
IGF1 decreases mitochondrial dysfunction in mouse cells.
“IGF-1 deficiency suppressed SLC25A33 expression in vitro, leading to mitochondrial ROS (mtROS) accumulation”
CellsIGF-1 deficiency in vitropericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Associations
1Age-related hearing loss
downin mice1
1 study
Age-related hearing loss
downin mice1
IGF1 is associated with age-related hearing loss in mice.
“Transcriptomics revealed significant downregulation of Igf1 and Slc25a33 in aged pericytes, with enrichment of the TGF-β signaling pathway.”
Animalspericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Latest
2Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.