Post-menopausal ER-positive breast cancer

1. Insulin/IGF-1 signalling has no effect on post-menopausal ER-positive breast cancer in humans (RD -8.4 per 1000 females, 95% CI -23.4 to 1.2).

   Humanseffect of adiposity on post-menopausal ER-positive breast cancerfemalesn = 1,260

   Mechanisms underlying the effect of adiposity on risk of post-menopausal oestrogen receptor-positive breast cancer: an interventional mediation analysis

   International journal of epidemiology·24 Jun 2026

More on Insulin/IGF-1 signalling

1. Sex hormone signalling (oestrogen, androgen) mediates post-menopausal ER-positive breast cancer in humans (RD 13.0 per 1000 females, 95% CI 3.3 to 23.7).

   Humanseffect of adiposity on post-menopausal ER-positive breast cancerfemalesn = 1,260

   Mechanisms underlying the effect of adiposity on risk of post-menopausal oestrogen receptor-positive breast cancer: an interventional mediation analysis

   International journal of epidemiology·24 Jun 2026

More on Sex hormone signalling (oestrogen, androgen)

1. Inflammation mediates post-menopausal ER-positive breast cancer in humans (RD 16.4 per 1000 females, 95% CI 4.3 to 27.2).

   Humanseffect of adiposity on post-menopausal ER-positive breast cancerfemalesn = 1,260

   Mechanisms underlying the effect of adiposity on risk of post-menopausal oestrogen receptor-positive breast cancer: an interventional mediation analysis

   International journal of epidemiology·24 Jun 2026

More on Inflammation

1. Obesity raises the risk of post-menopausal ER-positive breast cancer in humans (16.1 per 1000 females, 95% CI 3.3 to 30.4).

   Humansobesity relative to normal weightfemalesn = 1,260

   Mechanisms underlying the effect of adiposity on risk of post-menopausal oestrogen receptor-positive breast cancer: an interventional mediation analysis

   International journal of epidemiology·24 Jun 2026