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GH1

Gene

7 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Human trial2
  • Humans4

Effects

2

Body height

downin humans1

1 study

  1. GH1 decreases body height in humans (2 cm lower (P = 0.007)).

    “In females, for variant allele carriers of the GH1 SNP, body height was 2 cm lower (P = 0.007) and mortality 0.80-fold reduced (P = 0.019) when compared with wild-type allele carriers.”

    Humansfemales

    Reduced insulin/IGF-1 signalling and human longevity

    Aging cell1 Apr 2005

Mortality

downin humans1

1 study

  1. GH1 decreases mortality in humans (0.80-fold reduced (P = 0.019)).

    “In females, for variant allele carriers of the GH1 SNP, body height was 2 cm lower (P = 0.007) and mortality 0.80-fold reduced (P = 0.019) when compared with wild-type allele carriers.”

    Humansfemales

    Reduced insulin/IGF-1 signalling and human longevity

    Aging cell1 Apr 2005

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