ATRX
- 1 lab in 1 country
- Funders: Canadian Institutes of Health Research and 2 more
- Humans2
- Animals3
- Cells1
Effects
1Lifespan
downin mice2
2 studies
Lifespan
downin mice2
ATRX shortens lifespan in mice.
“conditional Atrx ablation in the mouse embryonic forebrain and anterior pituitary using the Foxg1cre driver causes reduced health and lifespan.”
Reviewin mice
Aging7 Jun 2018
ATRX shortens lifespan in mice.
“mutant mice displayed reduced growth, shortened life span, lordokyphosis, cataracts, heart enlargement, and hypoglycemia”
AnimalsAtrx loss
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span
The Journal of clinical investigation8 Apr 2013
Funding
2 grants since 2016Natural Sciences and Engineering Research Council of CanadaCA$21kCanadian Institutes of Health Research (CIHR) Project GrantCA$1k
The effects of ATRX on the chromatin landscape in senescence after growth arrest
Natural Sciences and Engineering Research Council of CanadaRockefeller UniversityCA$21k2023–2024
Investigation of premature-aging like phenotypes in ATRX mutant mice
Canadian Institutes of Health Research (CIHR) Project GrantUniversity of Western Ontario, CanadaCA$1k2016–2017
Latest
3 in 12 monthsZhonghua Xue Ye Xue Za Zhi
Somatic and immune profiling of chemotherapy-associated aplastic anemia: a comparison with primary aplastic anemia and cancer without aplastic anemia
Cohort study of 24 peopleImmune response
Laboratory Investigation; a Journal of Technical Methods and Pathology
Telomere Shortening and p16-Associated Senescence in Myofibromas
Cross-sectional study of 33 peopleTelomerase and telomere maintenance
Frontiers in Oncology
Effects of p53 and ATRX inhibition on telomeric recombination in aging fibroblasts
Experiments in human cellsTelomerase and telomere maintenance
The Journal of Clinical Investigation
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span
Experiments in miceTelomerase and telomere maintenance