Alpha-lipoic acid + climbing decreases peroxide in flies.
“Combined LA and climbing treatment significantly enhanced stress resistance and reduced peroxide levels in early- and mid-life flies, outperforming either intervention alone.”
Experiments in cells from the soft centre of spinal discs identified a protein that promoted iron build-up, damage to fats and cell aging.Experiments in cells from the soft centre of spinal discs identified a protein that promoted iron build-up, damage to fats and cell aging.
Experiments in nucleus pulposus cells, tissues, and animal modelsMechanisms
Limit: Unreported sample sizes make the robustness of the disc-cell findings difficult to assess
An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.
Experiments in rats with puncture-induced disc degeneration, 8 weeksInterventions
Limit: Only 5 rats per group contributed to the disc-preservation experiment
After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.
Experiments in aged male C57BL/6J mice, 7 daysLung
Limit: Assessment at 7 days leaves longer-term lung damage uncertain
In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.
In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.