No phaseCompletedAge-related condition
Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women
- Sponsor
- Marquette University (Academic or other)
- Enrolment
- 22 enrolled
- Conditions
- Aging
- Interventions
- Exercise
- Ages
- adults, older adults
- Registry
- NCT03888040
Full record on ClinicalTrials.gov
From the registry
The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older adults (Aim 3). The first two aims are cross-sectional studies comparing young (18-35 years old) and older adults (≥60 yrs old) to test our central hypothesis that the greater accumulation of metabolites and increase in fatigability in older adults is due to either age-related impairments in skeletal muscle bioenergetics (Aim 1) and/or vascular dysfunction (Aim 2). These two aims will integrate techniques to assess whole-muscle bioenergetics (31P-MRS) and in vivo vascular function (near infrared spectroscopy; NIRS and doppler ultrasonography) with in vitro assessment of single fiber bioenergetics (epifluorescence microscopy) and vasoreactivity of isolated skeletal muscle arterioles (video microscopy). We will then determine whether bioenergetics, vascular function and fatigability are…
Primary outcomes
- Change in Fatigability of the Knee Extensor Muscles From Baseline to After 8 Weeks Training
- Percent Change in Muscle Volume of the Quadricep Muscles Form Baseline to After 8 Weeks Training
- Change in Vascular Function Via Flow-mediated Dilation of the Femoral Artery From Baseline to After 8 Weeks of Training
History
Results posted
Last registry update
Study completion
Primary completion
Started
Registered