Lifestyle
Intervention4 papers4 findings
In one human study, lifestyle lowers dementia risk in a diabetes subgroup, whereas a review links lifestyle to increased colorectal and breast cancer risk in humans.
- Humans2
Outcomes
1Body mass index
downin humans1Low certainty
1 study
Body mass index
downin humans1Low certainty
Lifestyle decreases body mass index in humans.
“Favorable lifestyle behaviors were associated with lower BMI for all obesity endotypes”
Humansacross 10 obesity endotypes
Obesity Endotypes Unmask Heterogeneous Responses to Healthy Lifestyle Behaviors · medRxiv · 1 Sep 2026 · Preprint
Associations
3Dementia
downin humans1HR 0.33Low certainty
1 study
Dementia
downin humans1HR 0.33Low certainty
Lifestyle lowers the risk of dementia in humans (HR 0.33, 95% CI 0.14-0.79).
Humansin subgroup 1 of diabetes
Associations of diabetes subgroups and lifestyle with incident dementia: insights from unsupervised phenotype clustering analysis · Frontiers in endocrinology · 8 Sep 2026
Colorectal cancer
upin humans1
1 study
Colorectal cancer
upin humans1
Lifestyle raises the risk of colorectal cancer in humans.
Reviewcolorectal
Childhood, adolescent, and early adult exposures and cancer risk in middle to late adulthood · Carcinogenesis · 1 Jul 2026
Breast cancer
upin humans1
1 study
Breast cancer
upin humans1
Lifestyle raises the risk of breast cancer in humans.
Reviewbreast
Childhood, adolescent, and early adult exposures and cancer risk in middle to late adulthood · Carcinogenesis · 1 Jul 2026
Funding
National Institute on AgingUS$7.8mNational Cancer InstituteUS$5.8mNational Center for Chronic Disease Prev and Health PromoUS$5.6m41 grants since 2018
Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with Obesity
Veterans AffairsMichael E. DeBakey VA Medical Center2020–2026
National Institute on Minority Health and Health DisparitiesUniversity of FloridaUS$734.8k2026–2031
NDPP-MAP: A Lifestyle Intervention to Manage Health Risks After Pregnancy with Gestational Diabetes
National Institute of Diabetes and Digestive and Kidney DiseasesKaiser Foundation Research InstituteUS$829.9k2026–2031
National Institute on AgingWake Forest University Health SciencesUS$1.4m2019–2030
National Cancer InstituteUniversity of Tx Md Anderson Can CtrUS$680.6k2025–2030
National Institute of Neurological Disorders and StrokeUniversity of California, San DiegoUS$221.9k2025–2030
National Institute on AgingMassachusetts General HospitalUS$192.7k2022–2027
Implementing lifestyle change interventions to improve health outcomes
National Center for Chronic Disease Prev and Health PromoUniversity of Pittsburgh at PittsburghUS$503.1k2025–2029
Lifestyle Change Implementation Research Network at PRC at UMass Chan
National Center for Chronic Disease Prev and Health PromoUniv of Massachusetts Med Sch WorcesterUS$510.9k2025–2029
National Center for Chronic Disease Prev and Health PromoUniversity of UtahUS$1m2025–2029