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Phase 2Not yet recruitingGeroscience intervention

Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical Trial

Targeting Cellular Senescence With Fisetin for Improving Vascular Endothelial Function in Older Adults

Sponsor
University of Colorado, Boulder (Academic or other)
Enrolment
136 planned
Conditions
Aging; Endothelial Dysfunction; Cellular Senescence
Interventions
Fisetin; Placebo
Ages
older adults
Registry
NCT07871162

Full record on ClinicalTrials.gov

From the registry

Aging is associated with the development of vascular dysfunction, which increases the risk for cardiovascular disease. This clinical trial will assess if supplementation with the natural compound fisetin can improve vascular endothelial function in older adults. The clinical trial will also assess if any effects of fisetin on endothelial function are associated with reduced cellular senescence. The study will also evaluate safety, tolerability and adherence with fisetin treatment.

Primary outcomes

  • Change from baseline in endothelial function at 3 months

History

  1. Study completion expected

  2. Primary completion expected

  3. Expected to start

  4. Registered