Heat shock response and chaperones

Pathway8 papers3 findings

Animals1
Model organisms3
In silico1

Interventions

Turnera diffusa polysaccharides

upin model organisms1

1 study

Turnera diffusa polysaccharides activate heat shock response and chaperones.
Model organisms
Turnera diffusa polysaccharides promote healthy aging through conserved stress response regulation and metabolic remodeling across multiple aging models · Biogerontology · 25 Sep 2026

Turnera diffusa polysaccharides →

Effects

Loss of proteostasis

downin reviews1

1 study

Heat shock response and chaperones decrease loss of proteostasis.
Reviewcytosol/nucleus
More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

Loss of proteostasis →

Upstream

HSF1

upin reviews1

1 study

HSF1 activates heat shock response and chaperones.
Reviewduring loss of proteostasis in the cytosol/nucleuscytosol/nucleus
More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

HSF1 →

Latest

Life-History, Stress-Resistance, and Transcriptomic Variation Among a Mexican Caenorhabditis elegans Isolate and Contemporary and Ancestral N2 Lineages

Model organismsEcology and evolution3 h

Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR

In silicoPloS oneYesterday

Proteostasis and ageing dissidence

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1 Oct

Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1 Oct

More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1 Oct

Model organismsPeer-reviewed1 Oct

Nematode heat-shock protein HSP-12.6 selectively protects muscle thick filaments in vivo

The chaperone regulates lifespan in Caenorhabditis elegans and specifically shields myosin-containing structures without interacting with thin filaments or polyQ aggregates.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · Fern A et al.

Paper

AnimalsPeer-reviewed1 Oct

Circadian E3 ligase FBXL21 regulates daily muscle proteostasis by targeting DNAJB6

Loss of FBXL21 disrupts client protein degradation, worsening stress responses in muscle cells and mutant mice.

EMBO reports · Lim JY et al.

Paper

Turnera diffusa polysaccharides promote healthy aging through conserved stress response regulation and metabolic remodeling across multiple aging models

Model organismsBiogerontology26 Sep